Results 191 to 200 of about 1,303,488 (267)

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Interior Decorative VOCs Elevate T Cell‐Mediated Obstructive Lung Disease Risks via Osteogenesis‐Driven Lymphoid‐Biased Hematopoiesis

Advanced Science, EarlyView.
This study utilizes a whole‐body inhalation model to reveal that interior decorative VOCs exposure persistently elevates alveolar T cells. This increase is attributed to lymphoid‐biased hematopoiesis in the bone marrow, which is further driven by IL‐6/IL‐17A‐mediated osteogenic differentiation.
Hongyan Yu, Jingxu Zhang, Qingping Liu, Duxing Li, Ruonan Pan, Gan Miao, Yidi Chen, Zhe Kou, Guangbo Qu, Rong Zhang, Xiaoting Jin, Yuxin Zheng   +11 more
wiley   +1 more source

Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women. [PDF]

Cancers (Basel)
Ho PJ, Loo CKY, Lim RJY, Goh MH, Abubakar M, Ahearn TU, Andrulis IL, Antonenkova NN, Aronson KJ, Augustinsson A, Behrens S, Bodelon C, Bogdanova NV, Bolla MK, Brantley KD, Brenner H, Byers H, Camp NJ, Castelao JE, Cessna MH, Chang-Claude J, Chanock SJ, Chenevix-Trench G, Choi JY, Colonna SV, Czene K, Daly MB, Derouane F, Dörk T, Eliassen AH, Engel C, Eriksson M, Evans DG, Fletcher O, Fritschi L, Gago-Dominguez M, Genkinger JM, Geurts-Giele WRR, Glendon G, Hall P, Hamann U, Ho CYS, Ho WK, Hooning MJ, Hoppe R, Howell A, Humphreys K, Ito H, Iwasaki M, Jakubowska A, Jernström H, John EM, Johnson N, Kang D, Kim SW, Kitahara CM, Ko YD, Kraft P, Kwong A, Lambrechts D, Larsson S, Li S, Lindblom A, Linet M, Lissowska J, Lophatananon A, MacInnis RJ, Mannermaa A, Manoukian S, Margolin S, Matsuo K, Michailidou K, Milne RL, Mohd Taib NA, Muir KR, Murphy RA, Newman WG, O'Brien KM, Obi N, Olopade OI, Panayiotidis MI, Park SK, Park-Simon TW, Patel AV, Peterlongo P, Plaseska-Karanfilska D, Pylkäs K, Rashid MU, Rennert G, Rodriguez J, Saloustros E, Sandler DP, Sawyer EJ, Scott CG, Shahi S, Shu XO, Shulman K, Simard J, Southey MC, Stone J, Taylor JA, Teo SH, Teras LR, Terry MB, Torres D, Vachon CM, Houdt MV, Verhoeven J, Weinberg CR, Wolk A, Yamaji T, Yip CH, Zheng W, Hartman M, Li J, On Behalf Of The Abctb Investigators, kConFab Investigators, MyBrCa Investigators, Sgbcc Investigators.   +118 more
europepmc   +1 more source

Molecular epidemiology and clonality of Acinetobacter spp in a Lebanese hospital over a period of one year

, 2018
Micheline Soudeiha, Elie Salem Sokhn, Ziad Daoud, Dolla Karam Sarkis   +3 more
openalex   +2 more sources

Magnetically‐Induced Suppression of Oxidative Stress Prevents Venous Thrombosis

Advanced Science, EarlyView.
Venous thromboembolism (VTE) remains a leading cause of cardiovascular mortality. This study demonstrates that static magnetic fields (SMF) offer a novel non‐pharmacological intervention against VTE by mitigating endothelial oxidative stress. Mechanistically, SMF elevates intracellular Ca2+, boosts ATP production, and suppresses NOX4‐mediated ROS ...
Nana Zhang, Yirong An, Shiran Tao, Shenao Qu, Minge Wu, Guantong Fang, Ziqing Chen, Weilun Song, Haoze Leng, Rongqian Wu, Yi Lyu, Xiaoli Liu, Dinghui Dong   +12 more
wiley   +1 more source

Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy

Advanced Science, EarlyView.
This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li, Fulong Man, Jianwei Cheng, Li Chen, Yongyong Li, Haiqing Dong   +5 more
wiley   +1 more source

Macrophage‐Targeted Magnesium Ion‐Nourisher for NLRP3 Inflammasome Inhibition to Enhance Liver Inflammatory Disease Treatment

Advanced Science, EarlyView.
This report describes a nano magnesium nourisher, named MgC@PS, capable of targeted Mg2⁺ delivery to macrophages, effectively suppressing The nuclear factor kappa B (NF‐κB) activation and mitigating NLRP3 inflammasome‐driven pyroptosis in liver inflammation.
Li Wang, Zhuo Yan, Sindhu Yalavarthi, Yusif Abdul‐Rashid, Kiki Parker, Kyle Nowlin, Ethan Li, Jordan Mack, Josephine Wei, Hunter Vu, Zhenquan Jia, Jianjun Wei, Jilong Wang, Kerui Wu   +13 more
wiley   +1 more source

Neuroprotection and Axonal Regeneration via ECM‐Mimetic Nanofibers Incorporating Metal–Phenolic Network Nanoparticles Toward Spinal Cord Injury Repair

Advanced Science, EarlyView.
Metal–phenolic network (MPN) nanoparticles with neuroprotective functions are integrated into decellularized extracellular matrix (dECM) to obtain biomimetic composite fibrous scaffold MPN@dECM NFs by electrospinning, which protects spared neurons from secondary degeneration by suppressing excitotoxicity and inflammation, and promotes directional ...
Shu Chen, Bixue Wang, Qiya Zhang, Changsheng Liu, Xi Chen   +4 more
wiley   +1 more source

Role of Field Epidemiology in Environmental and Climate Change-Related Health Incidents in Wales: A Qualitative Analysis Through Expert Interviews. [PDF]

Int J Environ Res Public Health
Sonmez OF, Behbod B, Roberts C, Barracchia M, Baghinyan A, Indra L, Czabanowska K.   +6 more
europepmc   +1 more source

Comprehensive Measurement of Inter‐Individual Variation in DNA Repair Capacity in Healthy Individuals

Advanced Science, EarlyView.
Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai, Patrizia Mazzucato, Catherine Ricciardi, David C. Christiani, Liming Liang, Leona D. Samson, Isaac A. Chaim, Zachary D. Nagel   +7 more
wiley   +1 more source