Results 221 to 230 of about 1,553,026 (307)

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Local genomic epidemiology investigations of SARS-CoV-2 during the early pandemic response: A global systematic review. [PDF]

Epidemiol Infect
Morton LC, Forshey BM, Klinkhammer KE, Romaner A, Traore Z, Hartman LJ, Standley CJ, Roess AA.   +7 more
europepmc   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Frailty among older adults in Germany: regional variation across NAKO study centers. [PDF]

Int J Equity Health
König M, Rach S, Mikolajczyk R, Schöttker B, Mons U, Amthor M, Völzke H, Meinke-Franze C, Harth V, Obi N, Schulze MB, Thorand B, Greiser KH, Leitzmann M, Herrmann A, Lieb W, Kiekert J, Keil T, Krist L, Schmidt B, Heise JK, Nimptsch K, Pischon T, Ittermann T.   +23 more
europepmc   +1 more source

[Epidemiologies or epidemiology?].

Revista de saude publica, 1990
openaire   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Combining Observational Studies to Reduce Multiple Biases. [PDF]

Epidemiology
Cole SR, Zivich PN, Shook-Sa BE, Richardson DB, Hudgens MG, Edwards JK.   +5 more
europepmc   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Occupational exposure to chlorinated solvents and lung cancer: results of the SYNERGY case-control study. [PDF]

Occup Environ Med
Wan W, Vermeulen R, Portengen L, Olsson A, Schüz J, Bijoux W, Ahrens W, Barul C, Behrens T, Brüning T, Caporaso NE, Consonni D, Demers PA, Fabianova E, Fernández-Tardón G, Field J, Forastiere F, Foretova L, Ge CB, Gustavsson P, Janout V, Jöckel KH, Karrasch S, Kendzia B, Landi MT, Lissowska J, Mates D, McLaughlin J, Merletti F, Migliore E, Pándics T, Pohlabeln H, Radoï L, Richiardi L, Schejbalova M, Siemiatycki J, Świątkowska B, Wichmann HE, Zaridze D, Straif K, Kromhout H, Peters S.   +41 more
europepmc   +1 more source