Results 201 to 210 of about 2,098,761 (326)

PPARγ: a key orchestrator of epidermal barrier, immune responses, and lipid metabolism in atopic dermatitis pathogenesis and therapy. [PDF]

Front Allergy
Bao Y, Xu K, Du Y, Feng M, Li L, Li L, Yan G, Li X.   +7 more
europepmc   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Selected parameters of epidermal barrier in juveniles with type 1 diabetes correspond with the severity of diabetes - an observational study. [PDF]

Front Endocrinol (Lausanne)
Bogusz-Górna K, Polańska A, Dańczak-Pazdrowska A, Żaba R, Fichna P, Kędzia A.   +5 more
europepmc   +1 more source

Cytotoxicity, Epidermal Barrier Function and Cytokine Evaluation after Antiseptic Treatment in Bioengineered Autologous Skin Substitute. [PDF]

Biomedicines, 2022
García-Valdivia M, Quiñones-Vico MI, Ortega-Llamas L, Fernández-González A, Ubago-Rodríguez A, Sanabria-de la Torre R, Arias-Santiago S.   +6 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier. [PDF]

Nat Commun
Rudd JC, Smits JPH, Kuwong PT, Johnson RE, Monga LMN, van Vlijmen-Willems IMJJ, Porter GL, Halloran PO, Sharma K, Schmidt KN, Kumar V, Madson JG, Sarkar MK, van den Bogaard EH, Grunkemeyer JA, Gudjonsson JE, Wong SY, Simpson CL, Hansen LA.   +18 more
europepmc   +1 more source

Thermally Degradable Biocompatible Hydrogel as Transient Encapsulation Coating for Implantable Sensors

Advanced Science, EarlyView.
A biocompatible hydrogel coating with tissue‐like mechanics and reversible dissolution triggered by a mild, physiologically compatible temperature drop (≈37°C → ≈25°C) was developed for the transient encapsulation of implantable devices. The physically crosslinked methylcellulose, polyethylene glycol and polyacrilic acid (MC/PEG/PAA) hydrogel ...
Francesca Persano, Eleonora Vandini, Eleonora Daini, Antonietta Vilella, Daniela Giuliani, Leonardo Lamanna, Marco Friuli, Christian Demitri, Laura Pecoraro, Amilcare Barca, Tiziano Verri, Cosimino Malitesta, Martina Corsi, Giuseppe Barillaro, Elisabetta Mazzotta   +14 more
wiley   +1 more source

Impact of Exposome Factors on Epidermal Barrier Function in Patients with Obstructive Sleep Apnea Syndrome. [PDF]

Int J Environ Res Public Health, 2022
Romera-Vilchez M, Montero-Vilchez T, Herrero-Fernandez M, Rodriguez-Pozo JA, Jimenez-Galvez G, Morales-Garcia C, Buendia-Eisman A, Arias-Santiago S.   +7 more
europepmc   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

PEG-23 glyceryl distearate, a multifunctional skin-supporting material, upregulates the expression of factors associated with epidermal barrier and hydration. [PDF]

Int J Cosmet Sci
Miyoshi T, Keller BC, Nakagawa S, Ashino T, Numazawa S.   +4 more
europepmc   +1 more source