Results 71 to 80 of about 2,098,761 (326)

By protecting against cutaneous inflammation, epidermal pigmentation provided an additional advantage for ancestral humans. [PDF]

, 2019
Pigmentation evolved in ancestral humans to protect against toxic, ultraviolet B irradiation, but the question remains: "what is being protected?" Because humans with dark pigmentation display a suite of superior epidermal functions in comparison with ...
Abuabara, Katrina, Elias, Peter M, Lee, Chih-Hung, Lin, Tzu-Kai, Man, Mao-Qiang, Sheu, Hamm-Ming, Tsai, Jui-Chen, Wakefield, Joan S   +7 more
core   +1 more source

3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

Stem Cell Reports, 2014
Cornification and epidermal barrier defects are associated with a number of clinically diverse skin disorders. However, a suitable in vitro model for studying normal barrier function and barrier defects is still lacking.
Anastasia Petrova, Anna Celli, Laureen Jacquet, Dimitra Dafou, Debra Crumrine, Melanie Hupe, Matthew Arno, Carl Hobbs, Aleksandra Cvoro, Panagiotis Karagiannis, Liani Devito, Richard Sun, Lillian C. Adame, Robert Vaughan, John A. McGrath, Theodora M. Mauro, Dusko Ilic   +16 more
doaj   +1 more source

Selective ablation of Ctip2/Bcl11b in epidermal keratinocytes triggers atopic dermatitis-like skin inflammatory responses in adult mice. [PDF]

PLoS ONE, 2012
Ctip2 is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Selective ablation of Ctip2 in epidermis leads to increased transepidermal water loss (TEWL), impaired epidermal proliferation, terminal ...
Zhixing Wang, Ling-Juan Zhang, Gunjan Guha, Shan Li, Kateryna Kyrylkova, Chrissa Kioussi, Mark Leid, Gitali Ganguli-Indra, Arup K Indra   +8 more
doaj   +1 more source

Epidermal Acyl-CoA-binding protein is indispensable for systemic energy homeostasis

Molecular Metabolism, 2021
Objectives: The skin is the largest sensory organ of the human body and plays a fundamental role in regulating body temperature. However, adaptive alterations in skin functions and morphology have only vaguely been associated with physiological responses
Ditte Neess, Vibeke Kruse, Ann-Britt Marcher, Mie Rye Wæde, Julie Vistisen, Pauline M. Møller, Rikke Petersen, Jonathan R. Brewer, Tao Ma, Georgia Colleluori, Ilenia Severi, Saverio Cinti, Zach Gerhart-Hines, Susanne Mandrup, Nils J. Færgeman   +14 more
doaj   +1 more source

Role of Nitric Oxide in Regulating Epidermal Permeability Barrier Function

Experimental Dermatology, 2021
Nitric oxide (NO), a free radical molecule synthesized by nitric oxide synthases (NOS), regulates multiple cellular functions in a variety of cell types.
M. Man, J. Wakefield, T. Mauro, P. Elias
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [PDF]

, 2020
Netherton syndrome (NS) is a monogenic skin disease resulting from loss of function of lymphoepithelial Kazal-type-related protease inhibitor (LEKTI-1).
Butcher, Anna M, Cau, Laura, Dupont, Christopher L, Gallo, Richard L, Horswill, Alexander R, Hovnanian, Alain, Kaul, Drishti, Khalil, Shadi, Sanford, James A, Wang, Yichen, Williams, Michael R, Zaramela, Livia S, Zengler, Karsten   +12 more
core  

The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis [PDF]

, 2017
Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal disease of prematurity. Although the precise cause is not well understood, the main risk factors thought to contribute to NEC include prematurity, formula feeding, and bacterial ...
Bolock, Alexa M, Good, Misty, Hodzic, Zerina   +2 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Dihydroavenanthramide D Enhances Skin Barrier Function through Upregulation of Epidermal Tight Junction Expression

Current Issues in Molecular Biology
Skin barrier dysfunction and thin epidermis are hallmarks of sensitive skin and contribute to premature aging. Avenanthramides are the primary bioactive components of colloidal oatmeal, a commonly used treatment to enhance skin barrier function.
Jiye Park, Jae Young Shin, Daehyun Kim, Seung-Hyun Jun, Eui Taek Jeong, Nae-Gyu Kang   +5 more
doaj   +1 more source