Results 101 to 110 of about 18,565 (309)

Increased expression of matrix metalloproteinase-9 in patients with temporal lobe epilepsy [PDF]

, 2014
Aim: The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited.
Acar, Feridun, Acar, Göksemin, Demir, R., Tanriover, G.   +3 more
core   +1 more source

Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity

Advanced Science, EarlyView.
Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu, Philippa J. Karoly, Sina Mansour L., Artemio Soto‐Breceda, Levin Kuhlmann, Mark J. Cook, David B. Grayden   +6 more
wiley   +1 more source

Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review [PDF]

, 2009
Over-expression of P-glycoprotein (P-gp), the encoded product of the ATP-binding cassette (ABC), sub-family B, member 1 (ABCB1/MDR1) gene, plays an important role in mediating multidrug resistance to antiepileptic drugs (AEDs) in about 30% of patients ...
Haerian BS,, Lim KS,, Mohamed EHM,, Mohamed Z,, Raymond AA,, Tan CT,, Tan HJ,   +6 more
core  

Panayiotopoulos syndrome: a consensus view [PDF]

, 2006
The aim of this paper is to promote the correct classification of, and provide guidelines on, the diagnosis and management of panayiotopoulos syndrome (ps).
Alberto Verrotti, Athanasios Covanis, Aysin Dervent, Caraballo, Caraballo, Caraballo, Colin Ferrie, Covanis, Demirbilek, Despina Yalcin, Engel, Federico Vigevano, Ferrie, Ferrie, Ferrie, Gastaut, Gastaut, Gastaut, Gastaut, Gastaut, Gastaut, Gastaut, Harami Yoshinaga, Hirokazu Oguni, Kanazawa, Kazuyoshi Watanabe, Kivity, Kivity, Kivity, Koutroumanidis, Lada, Martinovic, Martinovic, Martinovic, Michael Koutroumanidis, Nahum, Oguni, Oguni, Oguni, Ohtsu, Panayiotopoulos, Panayiotopoulos, Panayiotopoulos, Panayiotopoulos, Panayiotopoulos, Panayiotopoulos, Roberto Caraballo, Sanders, Sara Kivity, Ueno, Verrotti, Verrotti, Verrotti, Veysi Demirbilek, Vigevano, Watanabe, Yalcin, Yoshinaga, Zarko Martinovic   +58 more
core   +1 more source

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

Rufinamide Use in Refractory Epilepsies

Archives of Epilepsy, 2015
The drug rufinamide was approved in November 2008 by the US Food and Drug Administration for use in the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in patients older than 4 years.
Abidin ERDAL, Yasemin AYDEMİR, F. Ezgi UÇAN TOKUÇ, Gizem ÖZDEMİR, Gülnihal KUTLU, Fatma GENÇ, Yasemin BİÇER GÖMCELİ   +6 more
doaj   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

Transparent Transfer‐Free Ultrasmall Multilayer Graphene Microelectrodes Enable High Quality Recordings in Brain Slices

Advanced Science, EarlyView.
A transfer‐free fabrication method enables multilayer graphene microelectrodes as small as 10 µm, eliminating reliability issues of manual graphene transfer. These electrodes record neural activity in brain slices with exceptional signal‐to‐noise ratios (up to 25–40 dB) while maintaining optical transparency for multimodal applications.
Nerea de Alvarez de Eulate, Christos Pavlou, Gonzalo León González, María Camarena Pérez, Lukas Holzapfel, Zhenyu Gao, Sten Vollebregt, Vasiliki Giagka   +7 more
wiley   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Study on the effect of quality of life with levetiracetam in the therapy for young epileptic patients

Chinese Journal of Contemporary Neurology and Neurosurgery, 2010
Objective To evaluate the effect of quality of life (QOL) in the refractoriness young epileptic patients of partial seizures with the neotype antiepileptic drugs (AEDs) of levetiracetam.
De SHI, Wei CHEN, Zhen⁃guo LIU
doaj