Results 111 to 120 of about 18,565 (309)

Sleep Related Epilepsy and Pharmacotherapy: An Insight

Frontiers in Pharmacology, 2018
In the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management.
Jaya Kumar, Amro Solaiman, Pasuk Mahakkanukrauh, Pasuk Mahakkanukrauh, Rashidi Mohamed, Srijit Das   +5 more
doaj   +1 more source

Out of the shadows : services for persons with epilepsy in Malta [PDF]

, 2000
Epilepsy is the most common neurological disorder in clinical practice and it is a generic term used to define a variety of seizure disorders. A seizure is a disturbance in the electrical activity of the brain. There are more than 20 different epilepsies
Mifsud, Janet
core  

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Single nucleotide variations in CLCN6 identified in patients with benign partial epilepsies in infancy and/or febrile seizures.

PLoS ONE, 2015
Nucleotide alterations in the gene encoding proline-rich transmembrane protein 2 (PRRT2) have been identified in most patients with benign partial epilepsies in infancy (BPEI)/benign familial infantile epilepsy (BFIE).
Toshiyuki Yamamoto, Keiko Shimojima, Noriko Sangu, Yuta Komoike, Atsushi Ishii, Shinpei Abe, Shintaro Yamashita, Katsumi Imai, Tetsuo Kubota, Tatsuya Fukasawa, Tohru Okanishi, Hideo Enoki, Takuya Tanabe, Akira Saito, Toru Furukawa, Toshiaki Shimizu, Carol J Milligan, Steven Petrou, Sarah E Heron, Leanne M Dibbens, Shinichi Hirose, Akihisa Okumura   +21 more
doaj   +1 more source

Early infantile epileptic encephalopathy type 4: clinical, neurophysiological and therapeutic aspects

Эпилепсия и пароксизмальные состояния, 2019
Objective. Study the clinical and neurophysiological evolution of early infantile epileptic encephalopathy type 4 (EIEE4) caused by a STXBP1 gene mutation.Material and methods.
A. A. Kholin, N. N. Zavadenko, L. M. Kolpakchi, I. D. Fedonyuk, A. S. Papikyan, А. N. Zavadenko, E. S. Ilina   +6 more
doaj   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

The efficacy and safety of zonisamide as adjunctive therapy in patients with partial seizure: a multicenter, randomized, double-blinded, placebo-controlled trial

Chinese Journal of Contemporary Neurology and Neurosurgery, 2011
Objective To evaluate the efficacy and safety of zonisamide (ZNS) as adjunctive therapy in patients with partial seizure or secondary generalized seizure, generalized tonic-clonic seizure (GTCS), absence seizure.
Lina ZHANG, Yajing LIU, Chengyun DING, Shugui SHI, Weihong LIN, Tao CHEN, Hongbin SUN, Yun XU, Wanli DONG, Qiguang CHEN, Bingwei CHEN, Yangmei CHEN   +11 more
doaj  

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy [PDF]

, 2017
Rolandic epilepsy (RE) is the most common idiopathic focal childhood epilepsy. Its molecular basis is largely unknown and a complex genetic etiology is assumed in the majority of affected individuals.
Ameil, Agnès, Andrieux, Joris, Becker, Albert J., Becker, Felicitas, Beckmann, Jacques S., Berkovic, Samuel F., Bouquillon, Sonia, Boute, Odile, Campus, Kiel, Claes, Lieve, Cuisset, Jean Marie, Cuvellier, Jean-Christophe, Dahl, Hans-Henrik M., David, Albert, de Flandre, Jeanne, De Jonghe, Peter, de Kovel, Carolien, de Vries, Bert, Deconinck, Tine, Delrue, Marie-Ange, Deprez, Liesbet, Doco-Fenzy, Martine, Elger, Christian E., Fernandez, Bridget A., Feucht, Martha, Feucht, Martha, Franke, Andre, Gaus, Verena, Geldner, Julia, Geldner, Julia, Gieger, Christian, Gruber-Sedlmayr, Ursula, Gruber-Sedlmayr, Ursula, Haberlandt, Edda, Haberlandt, Edda, Hahn, Andreas, Hamer, Hajo M., Helbig, Ingo, Herms, Stefan, Heron, Delphine, Hildebrand, Michael S., Hjalgrim, Helle, Hoffmann, Per, Jacquemont, Sebastien, Janz, Dieter, Keren, Boris, Kleefuß-Lie, Ailing A., Klein, Karl Martin, Klitten, Laura L., Koeleman, Bobby P.C., Kunz, Wolfram S., Lal, Dennis, Lal, Dennis, Lebel, Robert, Lebon, Sebastien, Leheup, Bruno, Lerche, Holger, Lerche, Holger, Lewis, Suzanne, Lindhout, Dick, Mefford, Heather, Mencarelli, Maria Antonietta, Mignot, Cyril, Minet, Jean-Claude, Moerman, Alexandre, Morice-Picard, Fanny, Mucciolo, Mafalda, Muhle, Hiltrud, Männik, Katrin, Mörzinger, Martina, Møller, Rikke S., Neophytou, Birgit, Neophytou, Birgit, Neubauer, Bernd, Neubauer, Bernd A., Nürnberg, Peter, Nürnberg, Peter, Oertel, Wolfgang H., Ostertag, Philipp, Ounap, Katrin, Pasquier, Laurent, Petit, Florence, Ragona, Francesca, Rajcan-Separovic, Evica, Regan, Brigid M., Reif, Philipp S., Reinthaler, Eva M., Reinthaler, Eva M., Renieri, Alessandra, Reymond, Alexandre, Rieubland, Claudine, Roche, Laurian, Roche, Laurian, Ronen, Gabriel M., Ronen, Gabriel M., Rosenow, Felix, Salengro, Roger, Sander, Thomas, Sander, Thomas, Sanlaville, Damien, Sarrazin, Elisabeth, Scheffer, Ingrid E., Schmitz, Bettina, Schoch, Susanne, Shen, Yiping, Silfhout, Anneke Vulto-van, Smets, Katrien, Steinböck, Hannelore, Steinböck, Hannelore, Stephani, Ulrich, Suls, Arvid, Surges, Rainer, Toliat, Mohammad R., Trucks, Holger, Van Dyck, Tine, van Haelst, Mieke, von Spiczak, Sarah, Waldenberger, Melanie, Weber, Yvonne, Weckhuysen, Sarah, Winterer, Georg, Wittig, Michael, Zimprich, Fritz, Zimprich, Fritz   +123 more
core  

The Faraday Scalpel: Electrochemical Nerve Lesioning Mechanisms Studied in Invertebrate Models

Advanced Science, EarlyView.
Direct‐current produces nerve lesioning through discrete electrochemical reactions. Using hypoxia‐sensitive locust nerves and hypoxia‐tolerant leech nerves, we map three injury pathways: cathodic oxygen reduction, cathodic alkalization, and anodic chloride oxidation. These findings establish electrochemical lesioning—the “Faraday Scalpel”—as a precise,
Petra Ondráčková, Jan Švec, Marie Jakešová, Jiří Ehlich, Imrich Gablech, Eric Daniel Głowacki   +5 more
wiley   +1 more source