Results 141 to 150 of about 10,519 (268)

Neurophysiological Recovery Following Nerve Transfer Surgery to Restore Upper Limb Function after Cervical Spinal Cord Injury

Annals of Neurology, EarlyView.
Objectives Nerve transfer is a promising intervention for restoring hand and upper limb function after cervical spinal cord injury (SCI), but the timeline of neurophysiological recovery in humans remains unclear. This study aimed to define recovery profiles after nerve transfers to restore upper limb function.
Kyle J. Missen, Justin M. Brown, Ross M. Mandeville, Harvey Wu, Sean Bristol, Peter K. Broadhurst, Erin Brown, Christopher Doherty, Amy K. Hanlan, Russell O'Connor, Lawrence R. Robinson, Kayton Rotenberg, J. Michael Hendry, Jana Dengler, Michael J. Berger   +14 more
wiley   +1 more source

Thalamic connectivity mirrors spatial maps of network dysfunction in nonlesional focal epilepsy. [PDF]

Epilepsia
Fan JM, Tadayon E, Kudo K, Ranasinghe KG, Findlay AM, Knowlton RC, Rao VR, Nagarajan SS.   +7 more
europepmc   +1 more source

Five Issues of Artificial Intelligence in Science: Sailing the Ship of Theseus

Annals of Neurology, EarlyView.
Artificial intelligence (AI) is becoming part of the working infrastructure of academic medicine. Because grants convert scientific ideas into protected time, infrastructure, and institutional priority, they provide a revealing test case for AI's effects on biomedicine. Five issues are emerging: language, agency, review, doership, and identity.
S. Thomas Carmichael
wiley   +1 more source

Efficacy of Levetiracetam in Patients With Pediatric Epilepsy: A Systematic Review and Meta-Analysis. [PDF]

Neurology
Balestrini S, Puliti D, Lombardini M, Bettiol A, Gasparini S, Lomonaco M, Presotto EM, Dalmazio Tarantino EP, De Masi S, Guerrini R.   +9 more
europepmc   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, EarlyView.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Long-term efficacy and safety of cannabidiol in patients with treatment-resistant focal epilepsies treated in the Expanded Access Program. [PDF]

Epilepsia
Patel AD, Szaflarski JP, Lyons PD, Boffa M, Greco T, Saurer TB, Rajasekaran K, Simontacchi KC, Thiele EA.   +8 more
europepmc   +1 more source

Maternal‐Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton, Ariane Beauvais, Rebecca Yaworski, Hugh J. McMillan, Rashmi Kothary   +4 more
wiley   +1 more source

Beyond Biomarkers: Empiric Immunotherapy in Refractory Epilepsy and the Search for Responders. [PDF]

Epilepsy Curr
Lapalme-Remis S.
europepmc   +1 more source

Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk

Annals of Neurology, EarlyView.
Objective ATP‐binding cassette transporter A1 (ABCA1) has been associated with Alzheimer's disease (AD), but the mechanisms by which it impacts disease risk are unknown. ABCA1 is known to bind apolipoprotein E (ApoE) and catalyze apolipoprotein lipidation.
Andrés Peña‐Tauber, Ricardo Hernández Arriaza, Dylan Reil, Manon Muntaner, Junyoung Park, Benjamin Grenier‐Boley, Marc Hulsman, Philippe Amouyel, Céline Bellenguez, Camille Charbonnier, Jean‐François Deleuze, Orio Dols‐Icardo, John Hardy, Henne Holstege, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Rebecca Sims, John van Swieten, Julie Willams, Jean‐Charles Lambert, Chaitan Khosla, Yann Le Guen, Michael D Greicius   +24 more
wiley   +1 more source

Thalamocortical circuits in idiopathic generalized epilepsies with different subsyndromes and preserved global functional architecture. [PDF]

Chin Med J (Engl)
Yang M, Lin T, Cao X, Zhang Y, Zhang T, Zhou H, Ren J, Li L, Gong Q, Zhou D, Yang T.   +10 more
europepmc   +1 more source