Results 191 to 200 of about 10,407 (218)

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, EarlyView.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Pediatric Investigation Plans for seizure and epilepsy treatments: An analysis since the implementation of the European Pediatric Regulation in 2006. [PDF]

Epilepsia
Agostini V, Auvin S.
europepmc   +1 more source

Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies. [PDF]

Epilepsia
Ellis CA, Ottman R, Epstein MP, Epi4K Consortium, Berkovic SF, Oliver KL.   +5 more
europepmc   +1 more source

Status Epilepsy Syndromes Made Easy: Pediatric Perspectives. [PDF]

Children (Basel)
Hon KLE, Leung AKC, Leung KKY, Torres AR.   +3 more
europepmc   +1 more source

Epilepsies and Mirror Movements: An Underrecognized Association? [PDF]

J Clin Med
Nardone R, Trinka E.
europepmc   +1 more source

The potential of laminar functional MRI in refining the understanding of epilepsy in humans. [PDF]

Brain
Aitken F, Winston JS, O'Muircheartaigh J, Carmichael DW.   +3 more
europepmc   +1 more source

Metabolic pathways and genes involved in treatable and non-treatable metabolic epilepsies. A comprehensive review and metabolic pathway analysis. [PDF]

Metab Brain Dis
Sesse A, Ladias P, Kostoulas C, Chatzistefanidis D, Georgiou I, Markoula S.   +5 more
europepmc   +1 more source

Old Lesions and New Targets: sEEG-Identified Onsets in Traditionally Inoperable Epilepsy Lesions and Associated Surgical Outcomes.

Pediatr Neurosurg
Dastagirzada YM, Frome S, Curry DJ, Weiner HL.   +3 more
europepmc   +1 more source

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Mechanism of gating and partial agonist action in the glycine receptor

Cell, 2021
Hongtao Zhu, Remigijus Lape, Timo Greiner   +2 more
exaly  

Factors governing partial coalescence in oil-in-water emulsions

Advances in Colloid and Interface Science, 2010
Koen Dewettinck
exaly