Results 211 to 220 of about 276,627 (258)

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

open access: yesAnnals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato   +7 more
wiley   +1 more source

N‐Alkoxysulfurdiimide Reagents for the One‐Step Modular Synthesis of Primary Sulfonimidamides

open access: yesAngewandte Chemie, EarlyView.
N‐Alkoxysulfurdiimide reagents when combined with organometallic reagents lead directly to primary sulfonimidamide products. The reactions are broad in scope, encompassing aryl, heteroaryl, and alkyl carbon substituents. The reactivity of the N‐alkoxysulfurdiimide reagents can be correlated with the electron‐withdrawing ability of the N‐substituent ...
Suzanne E. Davison   +6 more
wiley   +1 more source
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Epilepsy

Nature Reviews Disease Primers, 2018
Epilepsy affects all age groups and is one of the most common and most disabling neurological disorders. The accurate diagnosis of seizures is essential as some patients will be misdiagnosed with epilepsy, whereas others will receive an incorrect diagnosis. Indeed, errors in diagnosis are common, and many patients fail to receive the correct treatment,
Marco De Curtis   +2 more
exaly   +7 more sources

Epilepsy

Current Opinion in Neurology, 2007
The first Gamma Knife radiosurgery for mesial temporal lobe epilepsy was performed in Marseille in March 1993. Since then, around 130 patients have undergone epilepsy surgery using Gamma Knife at Marseille Timone University Hospital. The majority of epilepsy surgeries in our epilepsy surgery program in Marseille are performed conventionally because we ...
Jean, Régis   +2 more
openaire   +4 more sources

Epilepsy

Nursing Standard, 2016
The accurate diagnosis and classification of seizures is critical in informing prognosis and determining appropriate antiseizure treatments for patients with epilepsy. The electroencephalogram is the gold standard for diagnosis. Obtaining a thorough history, performing a careful physical examination, and selecting appropriate diagnostic studies are ...
Mackenzie C, Cervenka, Peter W, Kaplan
  +8 more sources

Epilepsy

New England Journal of Medicine, 2003
Seizures are common and are treated in all branches of medicine. Approximately 10% of the population will have one or more seizures during their lifetime. Seizures are symptoms that occur in acute illness, ie, provoked seizures, or in epilepsy, ie, unprovoked seizures.
Bernard S, Chang, Daniel H, Lowenstein
openaire   +4 more sources

Epilepsy

Neurological Sciences, 2008
MR is a fundamental step in the diagnostic path of patients with medically refractory partial epilepsy (MRPE) potentially amenable to surgery. The most frequent lesions harboured by these patients are: malformations of cortical development (MCD), mainly focal cortical dysplasias (FCD); epileptogenic tumours, such as dysembryoplastic neuroepithelial ...
Alberto, Citterio, Nadia, Colombo
openaire   +2 more sources

Epilepsy

2020
Epilepsy is considered a disease characterized by an underlying predisposition to seizures as well as neurobiologic, cognitive, psychologic, and social consequences. It is the most frequent chronic neurologic condition of childhood, affecting 0.5%-1% of children worldwide. It comprises a variety of disorders with many different etiologies, consequently
Bastos F, Cross JH
openaire   +5 more sources

Epilepsy

Current Opinion in Neurology, 2004
The purpose of this review is to consider the current and potential role of neuroimaging from an epilepsy perspective, and to illustrate that by combining appropriate imaging techniques, neuroimaging can contribute greatly to elucidating the basic mechanisms of the various forms of epileptic disorders.New magnetic resonance imaging sequences ...
Matthias J, Koepp, John S, Duncan
openaire   +2 more sources

Epilepsy

Neurologic Clinics, 2001
The successful management of epilepsy requires a thorough and individualized approach that accurately establishes the patient's seizure type(s) and, when appropriate, epilepsy syndrome. Selection of pharmacologic and nonpharmacologic therapy should be rational and tailored to each patient.
T R, Browne, G L, Holmes
openaire   +4 more sources

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