openaire +4 more sources
Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies
Objective Aggregation of misfolded α‐synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB) disease. Although evidence exists for aSyn “strains,” conformations with distinct biological properties, biomarkers for PD versus DLB are lacking.
George T. Kannarkat+17 more
wiley +1 more source
Adolescents' perspectives on health literacy interventions for reducing epilepsy misconceptions and stigma, and enhancing epilepsy management in Uganda. [PDF]
Kajumba MM+11 more
europepmc +1 more source
μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks
Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim+6 more
wiley +1 more source
Transcriptome profiling reveals major structural genes, transcription factors and biosynthetic pathways in refractory epilepsy in tropical region of China. [PDF]
Ben X+8 more
europepmc +1 more source
Deep Brain Stimulation for VPS16‐Related Dystonia: A Multicenter Study
Objective The objective was to evaluate the effects of deep brain stimulation (DBS) in an international cohort of patients with VPS16‐related dystonia. Methods This observational study collected preoperative and postoperative demographic, clinical, stimulation, genetic, neuroimaging, and neurophysiological data of medically refractory DYT‐VPS16 ...
Tatiana Svorenova+46 more
wiley +1 more source
Blood‑brain barrier dysfunction in epilepsy: Mechanisms, therapeutic strategies and future orientation (Review). [PDF]
Huang N+6 more
europepmc +1 more source
Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy
Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal+7 more
wiley +1 more source
High epilepsy prevalence and excess mortality in onchocerciasis-endemic counties of South Sudan: A call for integrated interventions. [PDF]
Amaral LJ+7 more
europepmc +1 more source