Results 141 to 150 of about 8,267 (258)

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen, Annelii Ny, Daniëlle Copmans, Jana Tits, Kenichi Kamata, Eva Gielis, Kevin Longin, Jo Sourbron, Peravina Thergarajan, Tracie Huey‐Lin Tan, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mastura Monif, Bridgette D. Semple, Christine Germeys, Benedetta Frizzi, Virginia Minniti, Sebastian Perrone, Carole L. Linster, Ilaria Elia, Ludo Van Den Bosch, Bruno P. A. Cammue, Arnout Voet, Lieven Lagae, Peter de Witte   +25 more
wiley   +1 more source

Trends in epilepsy surgery in Italy before and after the COVID‐19 pandemic: A nationwide study

Epilepsia, EarlyView.
Abstract Objective To study the current practice of epilepsy surgery in Italy and the relative impact of coronavirus disease 2019 (COVID‐19) pandemic on it. Methods We launched a survey through the Italian National Virtual Epilepsy Institute, to identify centers with epilepsy surgery programs and collect data on the current preoperative and surgical ...
Giuseppe Didato, Federico Vigevano, Laura Tassi, Renzo Guerrini, Marco de Curtis, Luca De Palma, Giancarlo Di Gennaro, Lino Nobili, Matteo Martinoni, Stefano Meletti, Domenica Battaglia, Elisabetta Cesaroni, Roberta Vittorini, Laura Grisotto, Giuseppe d'Orsi, Robertino Dilena, Valeria Pingue, Antonio Nardone, Federica Ranzato, Claudio Zucca, Paolo Bonanni, Pietro Mattioli, Gianpiero Tamburrini, Michela Quintiliani, Michele Luzi, Roberto Trignani, Francesca Torta, Giovanni Morana, Matteo Pugnaghi, Anna Elisabetta Vaudano, Francesca Bisulli, Elena Pasini, Alessandro Consales, Giulia Nobile, Vincenzo Esposito, Pier Paolo Quarato, Elena Freri, Carlo Efisio Marras, Flavio Giordano, Veronica Pelliccia, Laura Castana, Nicola Specchio, Umberto Costantino, Mauro Pluderi, Michele Rizzi, Diana Polo, Stefania Zambrano, Alberto Danieli, Flavio Villani, Carmen Barba, Italian Epilepsy Surgery Collaborative Group, Roberta Di Giacomo, Roberto Mai, Francesca Gozzo, Claudia Accolla, Elena Cavallini, Alfredo D’Aniello, Chiara Panzini, Stefano Francione, Lorenzo Ferri, Lidia Di Vito, Giada Giovannini, Niccolò Orlandi, Federico Bianchi, Massimo Valerio, Nicoletta Zanotta, Gianmarco Duma, Irene Pappalardo, Alessandro De Benedictis, Marco Locatelli, Domenico Tortora, Maria Camilla Rossi Espagnet, Ernesto Losavio, Luigi Giovanni Manfredi, Pietro Zeppa, Filomena Fuggetta, Massimo Carella, Paola Mattaliano, Anna Bellini   +78 more
wiley   +1 more source

Epileptogenesis in meningioma: Theories, putative biomarkers, and postoperative risk

Epilepsia, EarlyView.
Abstract Cranial meningioma are the most common type of primary brain tumor, and focal onset, tumor‐related seizures affect a significant proportion of patients. Seizures affect 30% of symptomatic preoperative patients and a further 12% of postoperative patients.
William H. Cook, Conor S. Gillespie, Ali Bakhsh, Anthony G. Marson, Michael D. Jenkinson, Adel E. Helmy   +5 more
wiley   +1 more source

Postneonatal epilepsy after acute provoked neonatal seizures: Incidence, predictors, and clinical burden in a multicenter cohort followed through early childhood

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a known potential outcome following acute provoked neonatal seizures, but its onset, treatment patterns, and health care utilization through childhood remain poorly characterized. This study aimed to define the incidence and timing of postneonatal epilepsy, identify perinatal predictors, and describe the clinical burden ...
Adam L. Numis, Hannah C. Glass, Janet S. Soul, Courtney J. Wusthoff, Shavonne L. Massey, Giulia M. Benedetti, Catherine J. Chu, Cameron Thomas, Tayyba Anwar, Monica E. Lemmon, Linda S. Franck, Madison M. Berl, Betsy Pilon, Stephanie M. D. Rau, Yi Li, Julie Sturza, Charles E. McCulloch, Renée A. Shellhaas   +17 more
wiley   +1 more source

Presence of interictal epileptiform EEG discharges implies increased risk of recurrence after the first unprovoked seizure: Report of the International League Against Epilepsy and International Federation of Clinical Neurophysiology

Epilepsia, EarlyView.
Abstract Objective A joint International Federation of Clinical Neurophysiology–International League Against Epilepsy (IFCN‐ILAE) Taskforce was created to explore the published evidence for initial EEG recordings in the evaluation of patients who experienced their first unprovoked seizure, and to determine the diagnostic value of EEG in supporting the ...
Betül Baykan, John Dunne, Samuel Wiebe, Louis Maillard, Sandor Beniczky, Michalis Koutroumanidis, Margitta Seeck   +6 more
wiley   +1 more source

Absence seizures and sleep–wake abnormalities in a rat model of GRIN2B neurodevelopmental disorder

Epilepsia, EarlyView.
Abstract Objective Pathogenic mutations in GRIN2B are an important cause of severe neurodevelopmental disorders resulting in epilepsy, autism, and intellectual disability. GRIN2B encodes the GluN2B subunit of N‐methyl‐d‐aspartate receptors (NMDARs), which are ionotropic glutamate receptors critical for normal development of the nervous system and ...
Katerina Hristova, Melissa C. M. Fasol, Niamh McLaughlin, Mohammad Sarfaraz Nawaz, Mehmet Taskiran, Ingrid Buller‐Peralta, Anjanette P. Harris, Andrew Sutherland, Alejandro Bassi, Adrian Ocampo‐Garces, Javier Escudero, Peter C. Kind, Alfredo Gonzalez‐Sulser   +12 more
wiley   +1 more source

Real‐world comparison of first‐line antiseizure monotherapy and the role of age at treatment initiation in newly diagnosed childhood epilepsy: A cohort study from a tertiary center

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate the real‐world effectiveness and tolerability of first‐line antiseizure medication (ASM) monotherapy in children with newly diagnosed epilepsy, focusing on comparative outcomes across developmental age groups and ASM types, and identifying clinical risk factors of treatment failure.
Ningshan Li, Huiting Zhang, Chaoran Yang, Xiaoying Qiao, Dezhi Cao, Lina Men, Guangjun Yu, Jianxiang Liao   +7 more
wiley   +1 more source

Detection of epileptic spasms using foundational AI and smartphone videos. [PDF]

NPJ Digit Med
Miron G, Halimeh M, Tietze S, Holtkamp M, Meisel C.   +4 more
europepmc   +1 more source

Long‐read sequencing of recurrent FGF12 duplications in epilepsy: Insights into structural mechanisms and aberrant isoforms

Epilepsia, EarlyView.
Abstract Objective Fibroblast growth factor 12 (FGF12), a member of the fibroblast homologous factor family, plays a key role in the modulation of voltage‐gated sodium (Nav) channels. Pathogenic variants in the FGF12 gene leading to a gain‐of‐function mechanism and partial duplication encompassing the FGF12 gene leading to a loss‐of‐function mechanism ...
Jade Fauqueux, Laurence Chaton, Pierre Cleuziou, Anne‐Sophie Diependaële, Nathalie Bach, Nicolas Gruchy, Marion Gerard, Jean‐Pascal Meneboo, Céline Villenet, Martin Figeac, Emilie Ait‐Yahya, Caroline Thuillier, Elise Boudry, Adeline Trauffler, Sylvie Nguyen‐The‐Tich, Simon Boussion, Roseline Caumes, Jamal Ghoumid, Thomas Smol   +18 more
wiley   +1 more source

Infantile epileptic spasms syndrome: a cohort study of 88 children. [PDF]

Ital J Pediatr, 2023
Ren LH, Zhang J, Li SX, Liu P, Chen H, Hu W.   +5 more
europepmc   +1 more source