Results 141 to 150 of about 8,257 (246)

"Time to Feed the Baby": Should There Be a Paradigm Change in the Treatment of Infantile Epileptic Spasms Syndrome? [PDF]

Epilepsy Curr
Phitsanuwong C.
europepmc   +1 more source

Update on Selected Adverse Events of Concern Following Immunization With Acellular Pertussis Vaccines, a Narrative Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim To provide an update paper on evidence of adverse events of concern following immunization (AEFI) with pertussis vaccines, focusing primarily on acellular (aP) vaccines. Methods Evidence was synthesised from epidemiological studies, systematic reviews over recent decades, expert interpretations in reviews from relevant research teams and ...
Lennart Nilsson, Jann Storsaeter
wiley   +1 more source

DTaP-induced infantile epileptic spasms syndrome high-risk window: Insights from school-age children. [PDF]

Hum Vaccin Immunother
Zhang Q, He W, Zhang MN, Hu LY, Shi XY, Wang YY, Lu Q, Wang QH, Liu LY, Zhao HQ, Wang J, Li JW, Zhao JB, Zhang Y, Wang J, Zou LP.   +15 more
europepmc   +1 more source

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source

Effectiveness, tolerability, and retention of the ketogenic diet for infantile epileptic spasms syndrome: a single-center cohort study. [PDF]

Front Neurol
Zhao F, Hu W, Zhang W, Lu Y, Li J, Zhang H.   +5 more
europepmc   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Targeting CRHR1 Signaling in Experimental Infantile Epileptic Spasms Syndrome: Evidence for Route-Dependent Efficacy. [PDF]

Children (Basel)
Chachua T, Yum MS, Chern CR, Vieira K, Velíšková J, Velíšek L.   +5 more
europepmc   +1 more source

EEG functional connectivity as a marker of evolution from infantile epileptic spasms syndrome to Lennox-Gastaut syndrome. [PDF]

Epilepsia
Romero Milà B, Liu VB, Smith RJ, Hu DK, Benneian NA, Hussain SA, Steenari M, Phillips D, Adams D, Skora C, Lopour BA, Shrey DW.   +11 more
europepmc   +1 more source

Telehealth Hammersmith Infant Neurological Examination and early diagnosis of cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To compare the performance characteristics of telehealth versus in‐person Hammersmith Infant Neurological Examination (HINE) assessment to support early diagnosis of cerebral palsy (CP). Method This study is a retrospective secondary analysis of prospectively collected HINE data from a neonatal intensive care follow‐up clinic, comparing ...
Jennifer C. Keene, Sarah L. Winter, Tara Dupont, Lauren Ayala, Wendy G. Evans, Betsy E. Ostrander   +5 more
wiley   +1 more source

Ketogenic drug tricaprilin (CER-0001) for the treatment of refractory infantile epileptic spasms: a phase 1/2a study. [PDF]

Front Pediatr
Cantillon M, Chen S, McIntyre N, Henderson ST, Riney K, Chan DWS, Lawson J, Chow L.   +7 more
europepmc   +1 more source