Results 171 to 180 of about 14,859 (310)
Modeling cerebral palsy in animals
Developmental Medicine &Child Neurology, EarlyView.Abstract Advancements in the treatment of cerebral palsy depend on animal research. Yet, most animal models have not been fully evaluated for spasticity and dystonia using clinically relevant measures of altered tone or movement patterns, which form the basis for diagnosing people with the condition.
Katharina A. Quinlan +8 more
wiley +1 more source
European Journal of Clinical Investigation, EarlyView.Globally, in 2021, there were 18.15 million prevalent cases of epilepsy in children and adolescents (8.24 and 9.91 million of idiopathic and secondary epilepsy, respectively). Between 1990 and 2021, the prevalence rate of secondary epilepsy increased by 16.14%, with especially high increases attributable to neonatal encephalopathy, neonatal jaundice ...
Yun Seo Kim +10 more
wiley +1 more source
Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate [PDF]
, 2018 Yasushi Iimura +16 more
openalex +1 more source
Epilepsia, EarlyView.Abstract Objective Epilepsy is a known potential outcome following acute provoked neonatal seizures, but its onset, treatment patterns, and health care utilization through childhood remain poorly characterized. This study aimed to define the incidence and timing of postneonatal epilepsy, identify perinatal predictors, and describe the clinical burden ...
Adam L. Numis +17 more
wiley +1 more source
Multimodal localization and surgery for epileptic spasms of focal origin: a review [PDF]
, 2018 Taylor J. Abel +4 more
openalex +1 more source
Absence seizures and sleep–wake abnormalities in a rat model of GRIN2B neurodevelopmental disorder
Epilepsia, EarlyView.Abstract Objective Pathogenic mutations in GRIN2B are an important cause of severe neurodevelopmental disorders resulting in epilepsy, autism, and intellectual disability. GRIN2B encodes the GluN2B subunit of N‐methyl‐d‐aspartate receptors (NMDARs), which are ionotropic glutamate receptors critical for normal development of the nervous system and ...
Katerina Hristova +12 more
wiley +1 more source
Study of the Effects of Mogadon in Treatment of Infantile Spasms
پزشکی بالینی ابن سینا, 2001 Among epileptic syndromes the infantile spasms ( west syndrome ) is the most malignant one and leads to irreparable brain damage, which is related directly to duration of spasms.
Mohammad Mahdi Taghdiri
doaj
Epilepsia, EarlyView.Abstract Objective This study was undertaken to evaluate the real‐world effectiveness and tolerability of first‐line antiseizure medication (ASM) monotherapy in children with newly diagnosed epilepsy, focusing on comparative outcomes across developmental age groups and ASM types, and identifying clinical risk factors of treatment failure.
Ningshan Li +7 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Fibroblast growth factor 12 (FGF12), a member of the fibroblast homologous factor family, plays a key role in the modulation of voltage‐gated sodium (Nav) channels. Pathogenic variants in the FGF12 gene leading to a gain‐of‐function mechanism and partial duplication encompassing the FGF12 gene leading to a loss‐of‐function mechanism ...
Jade Fauqueux +18 more
wiley +1 more source
Deciphering SCN2A: A comprehensive review of rodent models of Scn2a dysfunction
Epilepsia, EarlyView.Abstract SCN2A encodes for the alpha subunit of the voltage‐gated sodium channel NaV1.2, which is involved in action potential initiation and backpropagation in excitatory neurons. Currently, it is one of the highest monogenetic risk factors for both epilepsy and autism spectrum disorder.
Katelin E. J. Scott +2 more
wiley +1 more source