Results 191 to 200 of about 2,345,783 (392)

Increased Extra‐Axial Cerebrospinal Fluid Volume in Children With Angelman Syndrome: Links to Sleep Problems and Seizures

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Previous studies demonstrated that children with autism have enlarged volumes of extra‐axial cerebrospinal fluid (EA‐CSF) and an increased ratio of EA‐CSF to brain volume, indicating that EA‐CSF is disproportionally increased beyond macrocephaly often observed in autism.
Zumin Chen, Dea Garic, Yinuo Xu, Rachel G. Smith, Leigh Anne H. Weisenfeld, Sun Hyung Kim, Martin A. Styner, Joseph Piven, Benjamin D. Philpot, Heather C. Hazlett, Mark D. Shen   +10 more
wiley   +1 more source

Effectiveness of vagal nerve stimulation (VNS) in patients with drop-attacks and different epileptic syndromes [PDF]

, 2011
Nicola Zamponi, Claudia Passamonti, Elisabetta Cesaroni, Roberto Trignani, F. Rychlicki   +4 more
openalex   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First‐in‐Human Randomized, Double‐Blind, Placebo‐Controlled Single Ascending Dose Escalation Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R Srinivas, Randall Kaye   +6 more
wiley   +1 more source

Mechanisms of Epileptogenesis in Pediatric Epileptic Syndromes: Rasmussen Encephalitis, Infantile Spasms, and Febrile Infection-related Epilepsy Syndrome (FIRES)

Neurotherapeutics, 2014
C. Pardo, R. Nabbout, A. Galanopoulou
semanticscholar   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

The Clinical and Genetic Landscape of a French Multicenter Cohort of 2563 Epilepsy Patients Referred for Genetic Diagnosis. [PDF]

Eur J Neurol
de Sainte Agathe JM, Monin P, Riccardi F, Nava C, Arnaud L, Mignot C, Ville D, Auvin S, Tardieu S, Larcher K, Gourfinkel-An I, Canon M, Navarro V, Héron B, Julia S, Doummar D, Jacquemont ML, Maurey H, Dozières-Puyravel B, Perrin L, Pasquier L, Dubourg C, Odent S, Bouazzaoui A, Carre W, Fradin M, Demurger F, Chatron N, Sanlaville D, Essid M, Portes VD, Panagiotakaki E, Poulat AL, Rivier C, Sarret C, Remerand G, Altuzarra C, Stoeva R, Nguyen S, Piard J, Boucher É, Flurin V, Guerrot AM, Joriot S, Desnous B, Villeneuve N, Lépine A, Camus CH, Villard L, Faoucher M, Milh M, Lesca G, Leguern É.   +52 more
europepmc   +1 more source

Dravet syndrome—From epileptic encephalopathy to channelopathy

Epilepsia, 2014
A. Brunklaus, S. Zuberi
semanticscholar   +1 more source

Cannabidiol Lacks Direct Effect on Cortical Excitability: A Randomized, Double Blind, Placebo Controlled, 3‐Way Crossover Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Cannabidiol (CBD) is approved as an adjunctive treatment of seizures associated with Dravet syndrome, Lennox–Gastaut Syndrome, and tuberous sclerosis. Its therapeutic and adverse effects are thought to arise, at least partly, from a pharmacokinetic interaction with clobazam, another anti‐seizure medication (ASM).
Andriy A. Gorbenko, Catherine M.K.E. de Cuba, Annika A. de Goede, Titiaan E. Post, Roman Bohoslavsky, Pamela K. Strugala, Jules A.A.C. Heuberger, Geert Jan Groeneveld   +7 more
wiley   +1 more source

Introduction to Pediatric Epilepsy for Neuropsychology Students: A Literature Review [PDF]

, 2009
Silva, Marc A.
core   +1 more source

A novel germline PIGA mutation in Ferro‐Cerebro‐Cutaneous syndrome: A neurodegenerative X‐linked epileptic encephalopathy with systemic iron‐overload [PDF]

, 2013
Kathryn J. Swoboda, Rebecca L. Margraf, John C. Carey, Holly Zhou, Tara Newcomb, Emily Coonrod, Jacob Durtschi, Kalyan C. Mallempati, Attila Kumánovics, Ben E. Katz, Karl V. Voelkerding, John M. Opitz   +11 more
openalex   +1 more source