Results 51 to 60 of about 2,345,783 (392)

Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment

Neurobiology of Disease, 2013
Dravet syndrome is an intractable epileptic encephalopathy characterized by early onset epileptic seizures followed by cognitive decline, hyperactivity, autistic behaviors and ataxia.
Susumu Ito, Ikuo Ogiwara, Kazuyuki Yamada, Hiroyuki Miyamoto, Takao K. Hensch, Makiko Osawa, Kazuhiro Yamakawa   +6 more
doaj   +1 more source

Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current I_Na by Lamotrigine; A Potential for Acquired Arrythmias

Pharmaceuticals, 2022
Lamotrigine is widely prescribed to treat bipolar neurological disorder and epilepsy. It exerts its antiepileptic action by blocking voltage-gated sodium channels in neurons.
Juan Antonio Contreras Vite, Carlos Vega Valle, Happi Biekeu Mbem, Sarah-Maude Boivin, Robert Dumaine   +4 more
doaj   +1 more source

A case of Landau-Kleffner syndrome

Journal of Pediatric Critical Care, 2016
The Landau-Kleffner syndrome or the syndrome of acquired epileptic aphasia was first described in 1957. The disorder is characterized by gradual or rapid loss of language in a previously normal child.
Manjunath S Pandit, Ashok Gupta, Priyanshu Mathur, Manish Sharma, Manisha Garg   +4 more
doaj   +1 more source

Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine

PLoS ONE, 2015
Dravet syndrome (DS) is one of the most pharmacoresistant and devastating forms of childhood epilepsy syndromes. Distinct de novo mutations in the SCN1A gene are responsible for over 80% of DS cases.
Yifan Zhang, A. Kecskés, D. Copmans, M. Langlois, A. Crawford, B. Ceulemans, L. Lagae, P. D. de Witte, Camila V. Esguerra   +8 more
semanticscholar   +1 more source

The syndrome of isolated epileptic status [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1971
Within a group of 23 patients who presented with status epilepticus a syndrome is defined in which sudden unheralded status occurs in apparently healthy individuals. Recovery from the attack is complete and no other evidence of cerebral pathology may be found at the time.
C. W. M. Whitty, J. M. Oxbury
openaire   +2 more sources

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Potential therapeutic use of the ketogenic diet in autism spectrum disorders. [PDF]

, 2014
The ketogenic diet (KGD) has been recognized as an effective treatment for individuals with glucose transporter 1 (GLUT1) and pyruvate dehydrogenase (PDH) deficiencies as well as with epilepsy.
Dueñas, Nadia, Giulivi, Cecilia, Napoli, Eleonora   +2 more
core   +1 more source

Postictal Syndrome Associated with Epileptic Seizure

Archives of Epilepsy, 2020
Postictal syndrome (PIS) includes clinical, biological, electroencephalography and magnetic resonance imaging findings following the termination of a seizure.
Zeynep Ece KAYA GÜLEÇ, Seher Naz YENİ
doaj   +1 more source

Epileptic seizures in children with congenital Zika virus syndrome

Revista Brasileira de Saúde Materno Infantil
Objectives: to describe preliminary data referred to epileptic seizures and the probability of occurring these epileptic seizures in the infants' first months of life with congenital Zika virus (ZIKV) syndrome. Methods: concurrent cohort study including
Lucas Victor Alves, Danielle Di Cavalcanti Sousa Cruz, Ana Maria Campos van der Linden, Ana Rodrigues Falbo, Maria Júlia Gonçalves de Mello, Camila Esteves Paredes, Germanna Virginya Cavalcanti Silva, José Natal Figueiroa, Patrícia Gomes de Matos Bezerra   +8 more
doaj   +1 more source

Observational Study of Tocilizumab in Children With Febrile Infection‐Related Epilepsy Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to assess the efficacy and safety of using tocilizumab in children with febrile infection‐related epilepsy syndrome (FIRES) and explore tocilizumab‐related changes in interleukin (IL)‐6 levels. Methods Patients with FIRES admitted to the Intensive Care Unit (ICU) of Beijing Children's Hospital were retrospectively ...
Yushan He, Jie Wu, Chaonan Fan, Zheng Li, Jun Liu, Kechun Li, Quan Wang, Suyun Qian   +7 more
wiley   +1 more source