Results 191 to 200 of about 41,822 (309)

Chemogenetics with PSAM⁴-GlyR decreases excitability and epileptiform activity in epileptic hippocampus. [PDF]

Gene Ther
Gonzalez-Ramos A, Berglind F, Kudláček J, Rocha ER, Melin E, Sebastião AM, Valente CA, Ledri M, Andersson M, Kokaia M.   +9 more
europepmc   +1 more source

sEEG‐guided responsive neurostimulation to treat neocortical epilepsy: A multicenter retrospective study of the efficacy and safety of depth electrode‐mediated neuromodulation

Epilepsia Open, EarlyView.
Abstract Objectives Pivotal trials have established the effectiveness of the Responsive Neurostimulation System (RNS® System) in treating focal epilepsy. In clinical trials, depth leads were primarily used to treat mesial temporal seizure onsets while cortical strip leads were used to treat neocortical seizure onsets.
Sina Sadeghzadeh, David A. Purger, Priya Bhanot, Noriah Johnson, Daniel A. N. Barbosa, Yuhao Huang, Jay J. Park, Ethan Schonfeld, Matthew A. Abikenari, Bhav Jain, Joshua P. Aronson, Cornelia Drees, Tiffany L. Fisher, Jason Gerrard, Tyler E. Gray, Saadi Ghatan, Kevin Hines, Barbara C. Jobst, Ioannis Karakis, Steven G. Ojemann, Imran H. Quraishi, Ahmed M. Raslan, Michael D. Sather, Christopher T. Skidmore, Jon T. Willie, Chengyuan Wu, Ji Yeoun Yoo, Kevin D. Graber, Casey H. Halpern, Vivek P. Buch, Jonathon J. Parker   +30 more
wiley   +1 more source

Epileptiform activity in brain organoids derived from patient with Glucose Transporter 1 Deficiency Syndrome. [PDF]

Front Neurosci
Müller Y, Lengacher L, Friscourt F, Quairiaux C, Stoppini L, Magistretti PJ, Lengacher S, Finsterwald C.   +7 more
europepmc   +1 more source

Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers. [PDF]

Sci Rep, 2023
Hillebrand A, Holmes N, Sijsma N, O'Neill GC, Tierney TM, Liberton N, Stam AH, van Klink N, Stam CJ, Bowtell R, Brookes MJ, Barnes GR.   +11 more
europepmc   +1 more source

Centromedian nucleus targeting in the pediatric population treated with thalamic responsive neurostimulation for drug‐resistant epilepsy

Epilepsia Open, EarlyView.
Abstract The management of drug‐resistant epilepsy (DRE) in the pediatric population using neurostimulation of the centromedian (CM) nucleus of the thalamus (CMN) has been reported to be effective and safe. We present a case series of pediatric patients treated with responsive neurostimulation (RNS) and report on contact localization in relation to ...
Marian Michael Bercu, Bahram Sarvi Zargar, Kathryn E. Spykman, Gabe Heredia, Alon Y. Mogilner, Angel W. Hernandez, Sanjay E. Patra, David E. Burdette, Paul Ferrari   +8 more
wiley   +1 more source

Late‐onset unexplained epilepsy as a risk factor for cognitive impairment and dementia: Protocol for a multi‐center prospective longitudinal observational study (ELUCID)

Epilepsia Open, EarlyView.
Abstract Objective Late‐onset unexplained epilepsy (LoUE), defined as epilepsy onset after age 55 without an obvious cause, is an important risk factor for dementia. Studies have shown that 10%–25% of individuals with LoUE develop dementia within 3–4 years following their first seizure.
Alice D. Lam, Emily L. Johnson, Rani A. Sarkis, Leah J. Blank, Tyler E. Gaston, Mouhsin M. Shafi, Rodrigo Zepeda, Kyle R. Pellerin, Nathalie Jette, Douglas N. Greve, Lori B. Chibnik, Rebecca E. Amariglio, Gad A. Marshall, M. Brandon Westover   +13 more
wiley   +1 more source

Overexpression of BDNF Suppresses the Epileptiform Activity in Cortical Neurons of Heterozygous Mice with a Transcription Factor Sip1 Deletion. [PDF]

Int J Mol Sci
Turovskaya MV, Gavrish MS, Tarabykin VS, Babaev AA.   +3 more
europepmc   +1 more source

Semaphorin 4D induced inhibitory synaptogenesis decreases epileptiform activity and alters progression to Status Epilepticus in mice. [PDF]

Epilepsy Res, 2023
Adel SS, Clarke VRJ, Evans-Strong A, Maguire J, Paradis S.   +4 more
europepmc   +1 more source

ENCEVIS: Evaluating the feasibility of an AI‐based algorithm as an assistant to neurophysiologists in clinical practice

Epilepsia Open, EarlyView.
Abstract Objective This study evaluated the performance of the ENCEVIS artificial intelligence (AI)‐based algorithm as a screening tool to predict the presence of ictal and/or interictal epileptiform discharges (IEDs) in electroencephalography (EEG) recordings.
Aleksandre Tsereteli, Natela Okujava, Nikoloz Malashkhia, Tamar Sakvarelidze   +3 more
wiley   +1 more source

The diagnostic value of semiology, EEG and MRI in new‐onset pediatric bilateral tonic–clonic seizures: A multimodal analysis

Epilepsia Open, EarlyView.
Abstract Objective To assess the diagnostic contributions of semiology, Electroencephalography (EEG), brain magnetic resonance imaging (MRI), and longitudinal follow‐up both, individually and in combination in classifying seizure type (focal‐to‐bilateral tonic–clonic (FBTC) vs. generalized‐onset bilateral tonic–clonic (GBTC)) in children with new‐onset
Badiee Moussa, Wassim Nasreddine, Huda Abboodi, Ayman Beydoun, Ghassan Hmeimess, Jaafar Wazne, Abdel Rahman Shatila, Ahmad Beydoun   +7 more
wiley   +1 more source