Results 41 to 50 of about 41,822 (309)
Frontiers in Aging Neuroscience, 2022 Continually emerging data indicate that sub-clinical, non-convulsive epileptiform activity is not only prevalent in Alzheimer’s disease (AD) but is detectable early in the course of the disease and predicts cognitive decline in both humans and animal ...
Zackary A. Cope +2 more
doaj +1 more source
Benzodiazepine-induced epileptiform activity in vitro
Brain Research, 1987 Drug naive rat hippocampal slices were incubated in artificial cerebrospinal fluid (ACSF) containing 20 nM clonazepam, a concentration approximating those measured in the cerebrospinal fluid (CSF) of rats treated with high doses of clonazepam which resulted in behavioral hyperexcitability and convulsions upon withdrawal.
M F, Davies, S E, Sasaki, P L, Carlen
openaire +2 more sources
Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy [PDF]
, 2010 High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone.
Cmejla, Roman +5 more
core +3 more sources
Activity clamp provides insights into paradoxical effects of the anti-seizure drug carbamazepine [PDF]
, 2017 A major challenge in experimental epilepsy research is to reconcile the effects of anti-epileptic drugs (AEDs) on individual neurons with their network-level actions.
Kullmann, DM +5 more
core +1 more source
Dissociation of self-stimulation and epileptiform activity [PDF]
Electroencephalography and Clinical Neurophysiology, 1965 Dissociation of rhinencephalic or thalamic self- stimulation and epileptiform activity in ...
Bogacz, J. +2 more
openaire +3 more sources
Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]
, 1991 We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
core +2 more sources
Multimodal imaging of human brain activity: rational, biophysical aspects and modes of integration [PDF]
, 2009 Until relatively recently the vast majority of imaging and electrophysiological studies of human brain activity have relied on single-modality measurements usually correlated with readily observable or experimentally modified behavioural or brain state ...
Astolfi, L. +6 more
core +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Neurodegeneration with brain iron accumulation (NBIA) comprises a genetically and clinically heterogeneous group of rare neurological disorders characterized particularly by iron accumulation in the basal ganglia. To date, 15 genes have been associated with NBIA.
Seda Susgun +95 more
wiley +1 more source
Influence of the sevoflurane concentration on the occurrence of epileptiform EEG patterns.
PLoS ONE, 2014 Objectives and aimThis study was performed to analyse the effects of different sevoflurane concentrations on the incidence of epileptiform EEG activity during induction of anaesthesia in children in the clinical routine.BackgroundIt was suggested in the ...
Ines Kreuzer +3 more
doaj +1 more source
Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source