Results 91 to 100 of about 180,597 (336)

A rare mental foramen variation and the role of cone‐beam computed tomography in preventing nerve injury: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background The interforaminal space is frequently used for dental implant placement due to its strategic location between the bilateral mental foramina. However, neurosensory disturbances following surgical intervention near the mental foramen (MF) can occur in up to 43% of cases.
Magdalena Orlowska, Hend Abulatifa, Muhammad H. A. Saleh, Hom‐Lay Wang   +3 more
wiley   +1 more source

Applying DanGer Shock Eligibility Criteria to a Real‐World Cohort of Cardiogenic Shock Patients

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The DanGer Shock trial investigated the effects of adding a microaxial flow pump to guideline‐recommended therapy in patients with ST‐elevation myocardial infarction (STEMI)‐related cardiogenic shock (CS), finding a lower all‐cause mortality at 180 days in the intervention group.
Raffaela Miriam Planka, Lukas Herold, Theresa Glantschnig, Gudrun Sommer, Jonathan Pavek, Stefan Hatzl, Nicolas Verheyen, Christoph Strohhofer, Johannes Gollmer, Ewald Kolesnik, Martin Benedikt, Markus Wallner, Andreas Zirlik, Gabor Toth‐Gayor, Dirk von Lewinski   +14 more
wiley   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Small doses of epinephrine prolong the recovery from a rocuronium-induced neuromuscular block: a case report

BMC Anesthesiology, 2018
Background During anaesthesia it is not uncommon to administer epinephrine in patients blocked by non-depolarizing muscle relaxants. However, there are few reports on possible interaction of epinephrine with neuromuscular transmission in humans.
Hubert J. Schmitt
doaj   +1 more source

Derivatization of Small Molecules using Deuterated Analog of Reactive Matrix to Facilitate Identification in Mass Spectrometry Imaging

Chemistry–Methods, EarlyView.
The deuterated FMP‐10 analog, FMP‐10‐d3, enhances identification through isotopic labeling, providing structural insights via unique mass shifts. The approach improves the analysis of neurotransmitters and metabolites, facilitating neurochemical mapping and spatial metabolomics, with applications in neurodegenerative disease research. Mass spectrometry
Theodosia Vallianatou, Lorenzo Jacopo Ilic Balestri, Anna Nilsson, Xiaoqun Zhang, Per Svenningsson, Luke R. Odell, Per E. Andrén, Reza Shariatgorji   +7 more
wiley   +1 more source

THE EFFECT OF EPINEPHRINE ON THE PULMONARY CIRCULATION IN MAN 1 [PDF]

, 1951
A.Calhoun Witham, J. W. Fleming
openalex   +1 more source

Generation of Pseudo Metabolites as a Side Reaction in On‐Tissue Chemical Derivatization in Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Chemistry–Methods, EarlyView.
On‐tissue chemical derivatization reagents enhance sensitivity and specificity, but the impact of side reactions remains understudied. The reactive matrix FMP‐10 promotes Mukaiyama‐like condensation reactions between endogenous metabolites to form pseudo metabolites that are structurally identical to endogenous metabolites.
Tobias Bausbacher, Alessa L. Henneberg, Stephanie Meyer, Stefan Schmidt, Aubry K. Miller, Christiane A. Opitz, Carsten Hopf   +6 more
wiley   +1 more source

Profiling a Neo‐Antigen‐Driven Immune Response in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Study of the KLH Challenge Model

Clinical Pharmacology &Therapeutics, EarlyView.
Novel compounds targeting the adaptive immune system are commonly initially investigated in healthy volunteers (HV). HV frequently lack constitutively expressed drug‐target engagement biomarkers, complicating the evaluation of pharmacological activity. The keyhole limpet hemocyanin (KLH) neo‐antigen challenge elicits a controlled immune response in HV ...
Micha N. Ronner, Hendrika W. Grievink, Mahdi Saghari, Michelle Osse, Thierry P.P. van den Bosch, Jeffrey Damman, Marieke L. de Kam, Jacobus Burggraaf, Naomi B. Klarenbeek, Manon A. A. Jansen, Matthijs Moerland   +10 more
wiley   +1 more source

THE EFFECT OF ATROPINE AND SCOPOLAMINE ON THE SUBSEQUENT INJECTION OF EPINEPHRINE IN THYROTOXIC AND EUTHYROID PATIENTS [PDF]

, 1954
Stanley J. Sarnoff, Oliver Cope
openalex   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source