Results 121 to 130 of about 236,393 (384)

Profiling a Neo‐Antigen‐Driven Immune Response in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Study of the KLH Challenge Model

Clinical Pharmacology &Therapeutics, EarlyView.
Novel compounds targeting the adaptive immune system are commonly initially investigated in healthy volunteers (HV). HV frequently lack constitutively expressed drug‐target engagement biomarkers, complicating the evaluation of pharmacological activity. The keyhole limpet hemocyanin (KLH) neo‐antigen challenge elicits a controlled immune response in HV ...
Micha N. Ronner, Hendrika W. Grievink, Mahdi Saghari, Michelle Osse, Thierry P.P. van den Bosch, Jeffrey Damman, Marieke L. de Kam, Jacobus Burggraaf, Naomi B. Klarenbeek, Manon A. A. Jansen, Matthijs Moerland   +10 more
wiley   +1 more source

Use of Midodrine for Intraoperative Hemostasis in Cutaneous and Percutaneous Surgery

JID Innovations
Owing to the increasingly high volume of cutaneous and percutaneous procedures performed annually, the demand for local anesthesia has steadily risen. The gold-standard formulations for local anesthesia contain epinephrine at a concentration of 1:100,000
Joanna Dong, Naiem T. Issa, Michael Kaiser, Simonetta I. Gaumond, Michael Solis, Joel Gil, Robert S. Kirsner, Stephen C. Davis, Joaquin J. Jimenez   +8 more
doaj   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Intramuscular Epinephrine-Induced Transient ST-Elevation Myocardial Infarction

Journal of Investigative Medicine High Impact Case Reports, 2018
Introduction. Myocardial infarction in the setting of anaphylaxis may result from the anaphylaxis itself or from the epinephrine used to treat the anaphylaxis.
Binav Shrestha MBBS, Paritosh Kafle MBBS, Shivani Thapa MBBS, Suyash Dahal MBBS, Vijay Gayam MD, Alix Dufresne MD, FACP, FACC, FESC   +5 more
doaj   +1 more source

THE EFFECT OF BLOOD PRESSURE RISE ON THE PRODUCTION OF CYCLOPROPANE–EPINEPHRINE INDUCED CARDIAC IRREGULARITIES [PDF]

, 1949
Q. R. Murphy, Charles W. Crumpton, Walter J. Meek   +2 more
openalex   +1 more source

The Effects of Fire Fighting and On-Scene Rehabilitation on Hemostatis [PDF]

, 2010
Fire fighting is a dangerous occupation – in part because firefighters are called upon to perform strenuous physical activity in hot, hostile environments.
Fahey, George C., Fernhall, B., Horn, Gavin P., Illinois Fire Service Institute, Petruzzello, Steven J., Smith, Denise L., University of Illinois at Urbana-Champaign, Woods, Jeffrey   +7 more
core  

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Frequency of cardiotoxicity following intramuscular administration of epinephrine in emergency department patients with anaphylaxis

Journal of the American College of Emergency Physicians Open
Objectives Epinephrine can be a life‐saving treatment for patients with anaphylaxis. Potential cardiovascular side effects of epinephrine may contribute to clinician hesitancy to use it. However, the frequency of cardiotoxicity resulting from epinephrine
Emily K. Pauw, William B. Stubblefield, Jesse O. Wrenn, Sarah K. Brown, Millie S. Cosse, Zoe S. Curry, Terence P. Darcy, Tia'Asia E. James, Paige E. Koetter, Caitlin E. Nicholson, Frank N. Parisi, Laura G. Shepherd, Savannah L. Soppet, Michael D. Stocker, Bernard M. Walston, Wesley H. Self, Jin H. Han, Michael J. Ward   +17 more
doaj   +1 more source

Mid‐term survival in patients awaiting heart and kidney transplantation with Impella 5.5 support

ESC Heart Failure, EarlyView.
Abstract Background Patients with end‐stage heart failure and chronic kidney disease requiring dual‐organ transplantation (DOT) face significant challenges in utilizing durable mechanical circulatory support due to the risks associated with renal replacement therapies (RRTs) and multi‐organ failure.
Smruti Desai, Smit Paghdar, Jose Ruiz, Ji‐Min Jang, Sharan Malkani, Daniel S. Yip, Juan Leoni, Jose Nativi, Basar Sareyyupoglu, Kevin Landolfo, Si Pham, Parag Patel, Rohan Goswami   +12 more
wiley   +1 more source

Effects of Buffering and Preparation Time of Topical Anesthetics on Pain of Injection into Oral Mucosa

مجله دانشکده پزشکی اصفهان, 2012
Background: Many dental patients are afraid of injections. There are different methods for reducing pain during topical anesthetic injections. Some studies have reported buffering lidocaine to reduce injection pain.
Nasser Kaviani, Mojtaba Rahimi, Sayed Morteza Heidari, Zahra Rahmani   +3 more
doaj