Results 41 to 50 of about 166,252 (267)
A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection
Advanced Science, EarlyView.A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez +13 more
wiley +1 more source
Advanced Science, EarlyView.Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang +15 more
wiley +1 more source
Advanced Science, EarlyView.Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen +9 more
wiley +1 more source
A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function. [PDF]
, 2019 The intra-renal dopamine (DA) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressure homeostasis, as well as to the development of nephropathy.
Baker, Dewleen G +15 more
core +2 more sources
Effect of Lidocaine and Epinephrine on Human Erythrocyte Shape and Vesiculability of Blood Cells
Advances in Condensed Matter Physics, 2015 The effect of local anesthetic composed of lidocaine and epinephrine on vesiculability of blood cells and erythrocyte shape was studied. Whole blood and plasma were incubated with lidocaine/epinephrine.
Tanja Slokar +5 more
doaj +1 more source
Advanced Science, EarlyView.The SrCuSi4O₁₀ bioceramic particles mimic the effects of hot spring therapy by increasing the local wound temperature, which enhances the absorption of amino acids and stimulates cell metabolism. The amino acid uptake supports cellular glutathione redox reactions, helping to mitigate oxidative stress.
Bo Li +7 more
wiley +1 more source
Myocardial dysfunction after out-of-hospital cardiac arrest: predictors and prognostic implications. [PDF]
, 2018 We aim to determine the incidence of early myocardial dysfunction after out-of-hospital cardiac arrest, risk factors associated with its development, and association with outcome.
Gaieski, David Foster +5 more
core +1 more source
Advanced Science, EarlyView.Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner +14 more
wiley +1 more source
Implementation of anaphylaxis management guidelines [PDF]
, 2012 Anaphylaxis management guidelines recommend the use of intramuscular adrenaline in severe reactions, complemented by antihistamines and corticoids; secondary prevention includes allergen avoidance and provision of self-applicable first aid drugs.
Gough, Hannah +12 more
core +1 more source
Resuscitation PlusBackground: American Heart Association Pediatric Life Support guidelines recommend epinephrine administration via intravenous (IV) or intraosseous (IO) route, with endotracheal (ET) administration admissible in the absence of IV/IO access.
Megan O’Reilly +5 more
doaj +1 more source