Results 81 to 90 of about 6,358,133 (270)

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Limitations of standard memory assessments in breast cancer survivors

Translational Neuroscience
Breast cancer is the most commonly diagnosed cancer in women worldwide, and treatments like chemotherapy are often linked to post-treatment cognitive impairments, including memory deficits.
Bradley-Garcia Meenakshie, Tanguay Annick F.N., Haddad Gabriela, Jensen Adelaide, Sekeres Melanie J.   +4 more
doaj   +1 more source

Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1

eLife
The hippocampus is believed to encode episodic memory by binding information about the content of experience within a spatiotemporal framework encoding the location and temporal context of that experience.
William Hockeimer, Ruo-Yah Lai, Maanasa Natrajan, William Snider, James J Knierim   +4 more
doaj   +1 more source

A prefrontal-hippocampal comparator for goal-directed behavior: the intentional self and episodic memory

Frontiers in Behavioral Neuroscience, 2015
The hypothesis of this article is that the interactions between the prefrontal cortex and the hippocampus play a critical role in the modulation of goal-directed self-action and the strengthening of episodic memories.
Robert eNuman
doaj   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Replay of incidentally encoded novel odors in the rat

Animal Cognition
Although events are not always known to be important when they occur, people can remember details about such incidentally encoded information using episodic memory. Sheridan et al.
Cassandra L. Sheridan, Lauren Bonner, Jonathon D. Crystal   +2 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Time in mind: a multidisciplinary review on temporal perception, cognition, and memory

Frontiers in Cognition
This review examines temporal cognition through the lens of Mental Time Travel (MTT): the subjective experience of recalling past events and using them to construct future scenarios.
Jeffery R. L. Pendleton, Nicola S. Clayton   +1 more
doaj   +1 more source

A Novel Task for Studying Memory of Occasional Events in Rats

Bio-Protocol, 2016
Episodic memory has been defined in humans as the conscious recollection of unique personal past experiences often occurring singly during daily life, including remembrance of what happened, where and when it happened (Tulving, 1972).
Marina Allerborn, Alexandra Gros, Belkacem Messaoudi, Damien Gervasoni, Samuel Garcia, Marc Thevenet, Serge Laroche, Alexandra Veyrac, Nadine Ravel   +8 more
doaj   +1 more source

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

Advanced Science, EarlyView.
Mice can transfer the learned rule of spatial working memory to guide similar but novel tasks. Hippocampal CA3 populational activity dynamically reorganize during memory generalization, shifting from task‐specific to generalized coding over testing days. Sparse yet redundant neural representations of CA3 enable rule transfer and cognitive map formation,
Da Song, Zilu Zhu, Yujun Deng, Yujie Song, Hui Li, Junjun Ni, Zhenzhen Quan, Yan Yan, Hong Qing   +8 more
wiley   +1 more source