Results 71 to 80 of about 90,921 (287)

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Reconceptualizing Future Time Perspective Extension through Episodic Future Thinking

Revista de Psicología
Future time perspective extension is an individual's perception of the psychological distance between future goals. The concept of extension can be expanded to include how far into the future an individual habitual time space extends and the diffusion ...
Jenefer Husman, Matthew C. Graham, Drew White, Bradley Sullivan, Dean Livelybrooks   +4 more
doaj   +1 more source

Why are we not flooded by involuntary thoughts about the past and future? Testing the cognitive inhibition dependency hypothesis [PDF]

, 2019
© The Author(s) 2018In everyday life, involuntary thoughts about future plans and events occur as often as involuntary thoughts about the past. However, compared to involuntary autobiographical memories (IAMs), such episodic involuntary future thoughts ...
A Beech, A Chuderski, A D’Argembeau, A Field, Agnieszka Niedźwieńska, B Baird, B Eriksen, B Pageaux, B Plimpton, BJ Schmeichel, CM MacLeod, CT Ball, D Berntsen, D Berntsen, D Berntsen, D Berntsen, D Linden Van der, D Stawarczyk, DC Hoaglin, DC Hoaglin, DE Broadbent, DI Inouye, DL Schacter, FN Dempster, FT Anderson, GA Floridou, GA Shaw, H Finnbogadóttir, I Elua, I Suarez, J Dang, J Smallwood, J Smallwood, J Smallwood, J Smallwood, JC McVay, JC McVay, JM Smallwood, JM Tyler, JR Simon, JR Simon, JR Stroop, JS Warm, JT Nigg, K Barzykowski, K Barzykowski, K Barzykowski, K Barzykowski, KB Johannessen, KC Yam, Krystian Barzykowski, L Hasher, L Hasher, L Kvavilashvili, Lia Kvavilashvili, LM Jonkman, M Marwede, M Muraven, M Oaten, M Vannucci, M Vannucci, M Vannucci, M Wheeler, MA Conway, MA Conway, MA Conway, MA Conway, MJ Kane, MM Lorist, MS Hagger, NP Friedman, NR Spreng, OC Watkins, P Brzozowski, P Seli, R Radel, R Ratcliff, R Whelan, RA Barkley, Rémi Radel, S Kamiya, S Schlagman, S Schlagman, SN Cole, SN Cole, T Suddendorf, TA Salthouse, WPM Wildenberg Van Den, Y Zhang   +88 more
core   +3 more sources

Reduced Specificity in Episodic Future Thinking in Posttraumatic Stress Disorder [PDF]

Clinical Psychological Science, 2013
Posttraumatic stress disorder (PTSD), one of the most common disorders following trauma, has been associated with a tendency to remember past personal memories in a nonspecific, overgeneral way. The present study investigated whether such a bias also applies to projections of future personal events.
Kleim, Birgit, Graham, Belinda, Fihosy, Sonia, Stott, Richard, Ehlers, Anke   +4 more
openaire   +6 more sources

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Does thinking about the past reduce temporal discounting? An investigation into the effects of episodic thought on intertemporal choice [PDF]

, 2011
Humans show a preference for present rewards over delayed rewards, a phenomenon known as temporal discounting (TD). TD, of perennial interest because of its violation of rational economic theory, is associated with poor outcomes such as drug addiction ...
De La Vega, Alejandro
core   +2 more sources

Towards a shared ontology: a generic classification of cognitive processes in conceptual design [PDF]

, 2017
Towards addressing ontological issues in design cognition research, this paper presents the first generic classification of cognitive processes investigated in protocol studies on conceptual design cognition.
*Akin, *Akin, *Ball, *Bilda, *Bilda, *Bilda, *Chan, *Chen, *Chiu, *Daly, *Goel, *Jin, *Jin, *Kim, *Kim, *Kim, *Kim, *Kim, *Lane, *Lee, *Lloyd, *Maher, *Maher, *McNeill, *Park, *Sun, *Suwa, *Suwa, *Suwa, *Suwa, *Won, *Yu, *Yu, *Yu, *Yu, Abraham, Boyle, Bruce, Buys, Ericsson, Eysenck, Federmeier, Finke, Gero, Gero, Gero, Gobet, Kosslyn, Lloyd, Maher, McKoy, Newell, Rabbitt, Runco, Sim, Sim, Squire, Tulving, Tversky, van Someren   +59 more
core   +2 more sources

The temporal compression of events during episodic future thinking

Cognition, 2020
While the cognitive and neural mechanisms that underlie episodic future thinking are increasingly well understood, little is known about how the temporal unfolding of events is represented in future simulations. In this study, we leveraged wearable camera technology to examine whether real-world events are structured and compressed in the same way when
Jeunehomme, Olivier, Leroy, Nathan, D'Argembeau, Arnaud   +2 more
openaire   +3 more sources

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source