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Epistasis and genetic pathways
2020This chapter explains epistasis, whereby the phenotype of one gene masks the phenotype of a different gene, and describes how it can be exploited to construct the logical pathway of the gene interactions that underlie a biological process. It notes that every biological process is the outcome of genes or gene products working together in pathways and ...
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EPISTASIS AND THE EFFECT OF FOUNDER EVENTS ON THE ADDITIVE GENETIC VARIANCE [PDF]
Evolution, 1988 Models of founder events have focused on the reduction in the genetic variation following a founder event. However, recent work (Bryant et al., 1986; Goodnight, 1987) suggests that when there is epistatic genetic variance in a population, the total genetic variance within demes may actually increase following a founder event. Since the additive genetic
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Genetic interactions : epistasis, linkage and speciation
2019Population genetics often makes simplifying assumptions regarding the interactions between genes. Interactions between genes, whether through epistasis or linkage effects, vastly increase the complexity of mathematical modeling, and often require data that has not historically been available. In this Dissertation, I present three chapters that use this
Dagilis, Andrius Jonas +1 more
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Epistasis as a Source of Increased Additive Genetic Variance at Population Bottlenecks
Evolution, 1996The role of epistasis in evolution and speciation has remained controversial. We use a new parameterization of physiological epistasis to examine the effects of epistasis on levels of additive genetic variance during a population bottleneck. We found that all forms of epistasis increase average additive genetic variance in finite populations derived ...
James M. Cheverud, Eric J. Routman
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Pleiotropy, epistasis and the genetic architecture of quantitative traits
Nature Reviews GeneticsPleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis (whereby non-linear interactions between genetic polymorphisms affect the same trait) are fundamental aspects of the genetic architecture of quantitative traits.
Trudy F. C. Mackay, Robert R. H. Anholt
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Genetic testing in prostate cancer management: Considerations informing primary care
Ca-A Cancer Journal for Clinicians, 2022Veda N Giri +2 more
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Molecular imaging in oncology: Current impact and future directions
Ca-A Cancer Journal for Clinicians, 2022Martin G Pomper, Steven P Rowe
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
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Modern developments in germline pharmacogenomics for oncology prescribing
Ca-A Cancer Journal for Clinicians, 2022Natalie M Reizine, Peter H O'donnell
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