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EPISTASIS AND THE EFFECT OF FOUNDER EVENTS ON THE ADDITIVE GENETIC VARIANCE
Evolution, 1988Models of founder events have focused on the reduction in the genetic variation following a founder event. However, recent work (Bryant et al., 1986; Goodnight, 1987) suggests that when there is epistatic genetic variance in a population, the total genetic variance within demes may actually increase following a founder event. Since the additive genetic
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[Re-evaluation of genetic formulae and epistasis].
Genetika, 1989Experimental verification of some quantitative results, following from the new theory for investigation of non-allelic genes' interactions in the diallele analysis by Hayman was conducted. We postulated earlier a special kind of epistasis HC which is the new explication of epistasis j--the interaction between homozygote and heterozygote by Mather and ...
A N, Stroganov +2 more
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Artificial Immune Systems for Epistasis Analysis in Human Genetics
2010Modern genotyping techniques have allowed the field of human genetics to generate vast amounts of data, but analysis methodologies have not been able to keep pace with this increase. In order to allow personal genomics to play a vital role in modern health care, analysis methods capable of discovering high order interactions that contribute to an ...
Nadia M. Penrod +3 more
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Genetic testing in prostate cancer management: Considerations informing primary care
Ca-A Cancer Journal for Clinicians, 2022Veda N Giri +2 more
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Epistasis and deep learning in quantitative genetics
Deep learning (DL) methods are becoming increasingly common in biological research. While powerful in some contexts, it's often unclear what biological patterns DL models end up learning and how much of an advantage they provide over simpler alternatives.Sandler, George, York, Ryan
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Family Physicians and Referrals of Low-risk Women for BRCA1/2 Genetic Services
Ca-A Cancer Journal for Clinicians, 2009Mary Desmond Pinkowish
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Identifying genetic markers of adaptation for surveillance of viral host jumps
Nature Reviews Microbiology, 2010Kim M Pepin +2 more
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Genetic architecture: the shape of the genetic contribution to human traits and disease
Nature Reviews Genetics, 2017Nicholas J Timpson +2 more
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Population genetic testing for cancer susceptibility: founder mutations to genomes
Nature Reviews Clinical Oncology, 2015William D Foulkes +2 more
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