Results 41 to 50 of about 34,483 (232)

CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension

British Journal of Clinical Pharmacology, EarlyView.
Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien, Burabha Pussadhamma, Sirimas Kanjanawart, Thikhumporn Areesinpitak, Nontaya Nakkam, Chingching Foocharoen, Wichittra Tassaneeyakul, Suda Vannaprasaht   +7 more
wiley   +1 more source

Outcomes of out‐of‐hospital treatment of impending tonic–clonic status epilepticus with diazepam nasal spray: A retrospective combined cohort analysis

Epilepsia, EarlyView.
Abstract Objective We assessed the timing, dosing, and effectiveness of diazepam nasal spray in a large dataset of seizures treated in the out‐of‐hospital setting, using as reference the International League Against Epilepsy criteria for tonic–clonic status epilepticus (SE) and its treatment.
John M. Stern, Leock Y. Ngo, Eric B. Segal, Danielle A. Becker, Randa G. Jarrar, Tracy A. Glauser, Jurriaan M. Peters, Emilio Perucca, Evelyn K. Shih, Enrique Carrazana, Adrian L. Rabinowicz   +10 more
wiley   +1 more source

Acupuncture Alleviates Allergic Rhinitis by Activating the AMPK/PGC‐1α Pathway to Attenuate Mitochondrial Oxidative Stress and Restore Epithelial Barrier Function

Flavour and Fragrance Journal, EarlyView.
Acupuncture at Feishu (BL13), Shenshu (BL23), Yingxiang (LI20), and Dazhui (GV14) alleviates allergic rhinitis by activating the AMPK/PGC‐1α/NRF1/TFAM signalling axis. This activation improves mitochondrial biogenesis and function, reduces mtROS‐mediated oxidative stress, restores ATP production and respiratory complex I/IV activity, suppresses IgE and
Fengying Zhang, Wei Meng, Renzhong Wang, Huijun Du   +3 more
wiley   +1 more source

Development of a Machine Learning Algorithm for Differential Diagnosis Between Primary Immune Thrombocytopenia and Connective Tissue Disease‐Related Thrombocytopenia in Pediatric Patients

Journal of Clinical Laboratory Analysis, EarlyView.
Primary immune thrombocytopenia (ITP) and connective tissue disease‐related thrombocytopenia (CTD‐TP) share overlapping initial presentations in children, often leading to delayed diagnosis and suboptimal management. While existing literature focuses on therapeutic strategies, this study is the first to develop a machine learning (ML)‐based diagnostic ...
Furong Kang, Mei Yan, Yingbin Yue, Xuemei Wang, Yu Liu   +4 more
wiley   +1 more source

Endoscopic Cauterization of the Sphenopalatine Artery to Control Severe and Recurrent Posterior Epistaxis [PDF]

Iranian Journal of Otorhinolaryngology, 2013
Introduction: Epistaxis is one of the most common medical emergencies, making the management of posterior epistaxis a challenging problem for the ear, nose, and throat (ENT) surgeon.
Behrooz Gandomi, Mohammad Hosein Arzaghi, Bijan Khademi, Mohammad Rafatbakhsh   +3 more
doaj   +2 more sources

A nationwide multicenter observational study on childhood scurvy in Japan

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Although scurvy is rare in developed countries, cases in children with selective diets due to neurodevelopmental disorders have been increasingly reported in Japan. In this nationwide multicenter observational study, we aimed to clarify the clinical characteristics and diagnostic challenges faced by children with scurvy in Japan ...
Yu Masuda, Ryohei Fukatsu, Ryosuke Miyamoto, Hitoshi Honma, Yoshinori Ito, Hiromichi Shoji, Masanobu Kawai, Yuri Etani, Toshiaki Shimizu, Akihisa Okumura   +9 more
wiley   +1 more source

Delayed epistaxis after endoscopic transnasal pituitary tumor resection: clinical characteristics, risk factors, treatment and prevention

World Journal of Surgical Oncology
Background Delayed epistaxis after endoscopic transnasal pituitary tumor resection (ETPTR) is a critical complication, tending to cause aspiration or hemorrhagic shock. This study assessed clinical characteristics, risk factors, and provide treatment and
Chengzhi Mu, Zhenyu Song, Shengyuan Yu
doaj   +1 more source

Survey of Otolaryngologists on Delayed Epistaxis Following Posterior Nasal Nerve Ablation

International Forum of Allergy &Rhinology, EarlyView.
Jacob Schwartz, Carter Smith, Jose Luis Mattos   +2 more
wiley   +1 more source

Superior Labial Artery Flap for Septal Perforation Repair: The Boxer's Flap

The Laryngoscope, EarlyView.
The nasal floor flap, or Boxer's flap, is an anteriorly pedicled, superior labial artery–based mucosal flap that provides excellent closure rates in septal perforation repair when traditional septal flaps are not feasible. The schematic shows: (A) preoperative perforation, (B) nasal floor flap elevation (with the pedicle maintained at the inferior ...
Nicholas J. Campion, Zhanna Mokoyan, Viktoriya Stepanova, Isam Alobid, Richard J. Harvey, Yury Rusetsky   +5 more
wiley   +1 more source

Success of Anterior Ethmoidal Artery Flaps for Nasal Septal Perforation Repair: A Systematic Review

The Laryngoscope, EarlyView.
Nasal septal perforation (NSP) repair using the anterior ethmoidal artery (AEA) flap is an emerging endoscopic technique with an overall closure success rate of 84.6%. The AEA flap is a reliable endoscopic technique for repairing NSPs < 2.5 cm. Emerging AEA flap modifications may further improve outcomes, while enabling repair of larger perforations ...
Hemali P. Shah, Ethan Tsao, Alhan Sayyed, C. Scott Dorris, John R. Craig, Daniel B. Spielman   +5 more
wiley   +1 more source