Results 171 to 180 of about 56,845 (265)

The Regulation and Function of Hippo/YAP Pathway in Cancer

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discuss the core components of the Hippo/YAP pathway; its crosstalk with other signaling pathways; regulation by non‐coding RNAs; roles of YAP signaling in ...
Chinmoy Ghosh, Ruchi Kakar, Seline Torkamboor, Yue Sun   +3 more
wiley   +1 more source

Advancing Non-Invasive Diagnosis of Oral Epithelial Dysplasia: Comparative Insights from In Vivo Optical Coherence Tomography and Histopathology. [PDF]

J Clin Med
Jerjes W, Hamdoon Z, Rashed D, Hopper C.
europepmc   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

Artificial intelligence based vision transformer application for grading histopathological images of oral epithelial dysplasia: a step towards AI-driven diagnosis. [PDF]

BMC Cancer
Hadilou M, Mahdavi N, Keykha E, Ghofrani A, Tahmasebi E, Arabfard M.   +5 more
europepmc   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Feasibility study of single-image super-resolution scanning system based on deep learning for pathological diagnosis of oral epithelial dysplasia. [PDF]

Front Med (Lausanne)
Liu Z, Wang P, Deng N, Zhang H, Xin F, Yu X, Yuan M, Yu Q, Tang Y, Dou K, Zhao J, He B, Deng J.   +12 more
europepmc   +1 more source

Profiling Ten RHO GTPases in Myeloid Malignancies Reveals Distinct Expression Patterns and Prognostic Associations

Cancer Medicine, Volume 15, Issue 4, April 2026.
Expression of RHO GTPases in myeloid malignancies. Gene expression analysis of ten RHO GTPases revealed RHOBTB2, RND2, and RHOQ as differently expressed in patients with MDS and/or AML. RHOBTB2 was identified as a promising prognostic indicator. BM, bone marrow. MDS, myelodysplastic neoplasm. AML, acute myeloid leukemia.
Beatriz de Almeida Rodrigues, Luciana Bueno de Paiva, Maria Carolina Clares Ramalho, Amanda Ferreira Damasceno, Sara Teresinha Olalla Saad, Mariana Lazarini   +5 more
wiley   +1 more source

Understanding interobserver variability of pathologists to improve oral epithelial dysplasia grading. [PDF]

Oral Dis
Ng GTE, Phang SC, Yu KS, Tiwari L, Khurram SA, Sloan P, Kujan O.   +6 more
europepmc   +1 more source

Endoscopic–Histologic Discordance in Colorectal Small‐Cell Neuroendocrine Carcinoma: The Need for Deep Biopsies

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT In colorectal small‐cell neuroendocrine carcinoma, superficial endoscopic biopsies may be misleading due to predominant submucosal growth. When endoscopic features strongly suggest malignancy despite benign histology, deep biopsies and early multidisciplinary evaluation are essential.
Iacopo Verbo, Mattia Angelo Bez, Danilo Di Giorgio, Alessandro Verbo   +3 more
wiley   +1 more source

Odontogenic Keratocyst With Moderate Epithelial Dysplasia: A Rare Entity. [PDF]

Cureus
Vivekbalamithran V, Ramalingam K, Ramani P, Neralla M, Jason AS.   +4 more
europepmc   +1 more source