Results 171 to 180 of about 1,366,174 (281)

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

The Lid Wiper Effect on Corneal Epithelial Thickness Pattern in Healthy Eyes as Characterized by Zernike Analysis. [PDF]

Ophthalmol Sci
Yazbeck H, Assaf JF, Hong J, Li Y, Huang D.   +4 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning

Advanced Science, EarlyView.
SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley   +1 more source

Optical Quality of the Cornea After Orthokeratology Based on Total Corneal Refractive Power, Corneal Asphericity, and Epithelial Thickness: Protocol for a Prospective Quasi-Experimental Pre-Post Study. [PDF]

JMIR Res Protoc
Licari J, Medico-Salsench A, Medina-Guijarro L, Villa-Collar C, Rey-Reñones C.   +4 more
europepmc   +1 more source

Changes in Corneal Biomechanics and Epithelial Thickness in High Myopia Over -8.00D with/without Myopic Regression After Femtosecond Laser-Assisted in Situ Keratomileusis. [PDF]

Clin Ophthalmol
Shao T, Li H, Peng Y, Zhang J, Wang H, Long K.   +5 more
europepmc   +1 more source

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

Advanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu, Qinqin Li, Yumin Chen, Shihan Zhang, Shuai Ding, Yanpei Wang, Youxing Liu, Yaru Guo, Xuliang Deng, Shaojun Guo   +9 more
wiley   +1 more source

Anterior Segment Optical Coherence Tomography Epithelial Thickness Mapping for Lesion Delineation in Recurrent Corneal Erosion: A Paired-Method Study. [PDF]

Transl Vis Sci Technol
Huang WL, Chen JH, Chen LY, Hu YC, Lin IH, Hou YT, Yeh HH, Chu HS, Chen WL.   +8 more
europepmc   +1 more source

Epithelial-to-Mesenchymal Transition in Breast Cancer: A Multi-Level Study Integrating Patient Tissues, Sera, and Cellular Systems

The epithelial-to-mesenchymal transition (EMT) is a complex process pivotal in embryonic development, wound healing, and tumor progression, particularly in breast cancer (BC), a heterogeneous disease in which patients diagnosed at the same stage exhibit ...
PERI, Emanuela
core  

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source