Results 291 to 300 of about 311,587 (357)

Putative Biomarkers for Prognosis, Epithelial-to-Mesenchymal Transition, and Drug Response in Cell Lines Representing Oral Squamous Cell Carcinoma Progression. [PDF]

Genes (Basel)
Hamoui MZ, Rizvi S, Arnouk H, Roberts CM.   +3 more
europepmc   +1 more source

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer

Advanced Science, EarlyView.
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang, Guozhi Zhang, Zhizhao Zhang, Mengsi Zhang, Jiao Chen, Ke Wang, Lu Liu, Jing Bao, Ming Chen, Xiaowei Qi, Mingxuan Gao   +10 more
wiley   +1 more source

Retraction: KMT2C Mutations in Diffuse-Type Gastric Adenocarcinoma Promote Epithelial-to-Mesenchymal Transition. [PDF]

Clin Cancer Res
Cho SJ, Yoon C, Lee JH, Chang KK, Lin JX, Kim YH, Kook MC, Aksoy BA, Park DJ, Ashktorab H, Smoot DT, Schultz N, Yoon SS.   +12 more
europepmc   +1 more source

Transtorming Growth Factor β1 Induces Epithelial-to-Mesenchymal Transition of A549 Cells

, 2007
Ju Hee Kim, Young Sook Jang, Kwang-Seok Eom, Young Il Hwang, Hae Raen Kang, Seung Hun Jang, Cheol Hong Kim, Yong Bum Park, Myung Goo Lee, In Gyu Hyun, Ki‐Suck Jung, Dong-Gyu Kim   +11 more
openalex   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling. [PDF]

J Clin Invest
Tao B, Wang Z, Wang X, Song A, Liu J, Wang J, Zhang Q, Chen Z, Wang Z, Xu W, Sun M, Wang Y, Zhang P, Xu T, Wei GH, Chen FX, Wang M.   +16 more
europepmc   +1 more source

Plasmin(ogen) Promotes Renal Interstitial Fibrosis by Promoting Epithelial-to-Mesenchymal Transition

, 2007
Guoqiang Zhang, Kelly Kernan, Sarah Collins, Xiaohe Cai, Jesús M. López-Guisa, Jay L. Degen, Yigal Shvil, Allison A. Eddy   +7 more
openalex   +1 more source

Neoadjuvant Chemotherapy With Cisplatin Up‐Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14‐Mediated EMT Activation

Advanced Science, EarlyView.
Oral squamous cell carcinoma cells exhibit upregulated expression of GSDMD upon exposure to low‐dose cisplatin chemotherapy, which subsequently interacts with MMP14 through its N‐terminal domain, activating the epithelial‒mesenchymal transition (EMT) process and promoting the lymph node metastasis of oral squamous cell carcinoma.
Zixian Huang, Qiming Jiang, Qianyu Zhang, Nan Lu, Xi Rui, Rui Chen, Yan Wang, Yuepeng Wang, Xiaoding Xu, Zhiquan Huang   +9 more
wiley   +1 more source

Knockdown of Plexin C1 induces epithelial-to-mesenchymal transition and confers resistance to multikinase inhibitors in hepatocellular carcinoma cells. [PDF]

Turk J Biol
Topcu GG, Aysan A, Dik Ş, Şeker M, Bahçekapili MB, Topkaraoğlu S, Yavuzer D, Yağci T.   +7 more
europepmc   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source