Results 311 to 320 of about 395,501 (352)

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Computational design of a glycosylated multi-epitope vaccine against HAsV-1 and HAsV-2 astrovirus for acute gastroenteritis. [PDF]

Sci Rep
Naveed M, Ali A, Aziz T, Ali N, Rehman HM, Khan AA, Ul Haq T, El Hadi Mohamed RA, Al-Asmari F, Alwethaynani MS, Al-Joufi FA, Fallatah D.   +11 more
europepmc   +1 more source

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

Advanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang, Xiaoshuang Niu, Ye Su, Xiaoyun Ye, Wanqiong Li, Wenxuan Zeng, Xin Zhao, Zhuoying He, Qingyu Dong, Xiuman Zhou, Xinghua Sui, Guanyu Chen, Yanfeng Gao, Juan Liu   +13 more
wiley   +1 more source

Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis. [PDF]

Front Immunol
Cao H, Cao Z, Han Y, Shan J.
europepmc   +1 more source

Immunoinformatic evaluation for the development of a potent multi-epitope vaccine against bacterial vaginosis caused by Gardnerella vaginalis. [PDF]

PLoS One
Motamedi H, Shoja S, Abbasi M.
europepmc   +1 more source

Distinct Omicron longitudinal memory T cell profile and T cell receptor repertoire associated with COVID-19 hospitalisation. [PDF]

Front Immunol
Markey G, McLaughlin J, McDaid D, Lynch SM, English A, Alexander HD, Kelly M, Bhavsar M, McGilligan V, Zhang SD, Murray EK, Rai TS, Walsh C, Bjourson AJ, Shukla P, Gibson DS.   +15 more
europepmc   +1 more source

Pan-Variant SARS-CoV-2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes. [PDF]

Adv Sci (Weinh)
Shah M, Moon SU, Shin JY, Choi JH, Kim D, Woo HG.   +5 more
europepmc   +1 more source

Characterizing HLA-A2-restricted CD8⁺ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients. [PDF]

Front Immunol
Xiao C, Xiang J, Wang H, Gao W, Peng T, Li S, Su J, Chen X, Gao L, Shi R, Mou X, Yuan J, Chen G.   +12 more
europepmc   +1 more source

Advancing one health vaccination: In silico design and evaluation of a multi-epitope subunit vaccine against Nipah virus for cross-species immunization using immunoinformatics and molecular modeling. [PDF]

PLoS One
Banico EC, Sira EMJS, Fajardo LE, Dulay ANG, Odchimar NMO, Simbulan AM, Orosco FL.   +6 more
europepmc   +1 more source