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T-cell epitopes of aeroallergens
Annals of Allergy, Asthma & Immunology, 2009To describe the current knowledge of the T-cell epitopes of common aeroallergens, how they were discovered, and implications for future therapy.PubMed search of English-language articles without date limits pertaining to T-cell epitopes of aeroallergens included on a standard skin test panel.A total of 127 articles were screened based on the results of
Adrian G. Letz, Christopher W. Calabria
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Prediction of Antibody Epitopes
2015Antibodies recognize their cognate antigens in a precise and effective way. In order to do so, they target regions of the antigenic molecules that have specific features such as large exposed areas, presence of charged or polar atoms, specific secondary structure elements, and lack of similarity to self-proteins.
Morten Nielsen +2 more
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An Introduction to Epitope Mapping
2018Antibodies are protein molecules used routinely for therapeutic, diagnostic, and research purposes due to their exquisite ability to selectively recognize and bind a given antigen. The particular area of the antigen recognized by the antibody is called the epitope, and for proteinaceous antigens the epitope can be of complex nature.
Johan Rockberg, Johan Nilvebrant
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Seminars in Oncology, 2006
Variable expression of the HER2 receptor has been implicated in the pathogenesis of a number of malignancies. Many therapeutic modalities have been devised that target the receptor and downstream molecular pathways. The humanized monoclonal antibodies trastuzumab and pertuzumab bind epitopes on the extracellular domain, resulting in cell growth ...
Mark D. Pegram, Sumanta Kumar Pal
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Variable expression of the HER2 receptor has been implicated in the pathogenesis of a number of malignancies. Many therapeutic modalities have been devised that target the receptor and downstream molecular pathways. The humanized monoclonal antibodies trastuzumab and pertuzumab bind epitopes on the extracellular domain, resulting in cell growth ...
Mark D. Pegram, Sumanta Kumar Pal
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2016
The original scientific strategy behind vaccinology has historically been to “isolate, inactivate, and inject,” first invoked by Louis Pasteur. Subsequently, this empirical approach dominated the vaccine development over 80 years. The recombinant DNA technology arised, and in 1980 the first recombinant vaccine against hepatitis B virus was presented ...
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The original scientific strategy behind vaccinology has historically been to “isolate, inactivate, and inject,” first invoked by Louis Pasteur. Subsequently, this empirical approach dominated the vaccine development over 80 years. The recombinant DNA technology arised, and in 1980 the first recombinant vaccine against hepatitis B virus was presented ...
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Current Opinion in Immunology, 1996
Synthetic approaches to T-cell epitope determination have recently been developed that complement the search for natural T-cell epitopes and the investigation of the preferences of the different MHC alleles for particular motifs in cognate peptide sequences. The combination of these different strategies opens new possibilities for basic, as well as for
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Synthetic approaches to T-cell epitope determination have recently been developed that complement the search for natural T-cell epitopes and the investigation of the preferences of the different MHC alleles for particular motifs in cognate peptide sequences. The combination of these different strategies opens new possibilities for basic, as well as for
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2009
The current challenge in synthetic vaccine design is the development of a methodology to identify and test short antigen peptides as potential T cell epitopes. A HLA-peptide binding model (using structural properties) capable of predicting peptides binding to any HLA allele has been described in Chap. 7.
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The current challenge in synthetic vaccine design is the development of a methodology to identify and test short antigen peptides as potential T cell epitopes. A HLA-peptide binding model (using structural properties) capable of predicting peptides binding to any HLA allele has been described in Chap. 7.
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Cryptic epitope and autoimmunity
Diabetes / Metabolism Reviews, 1998Micheal S. Lan, Noel K. Maclaren
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Epitope Mapping by a Combination of Epitope Excision and MALDI-MS
2003Carol E. Parker, Kenneth B. Tomer
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