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HLA-B21 is not an epitope, but a cluster of different epitopes
Human Immunology, 2015Aim Definition of the anti-HLA-B21 antibody specificity in terms of amino acid sequence properties of the target alleles. Methods Antibody specificities are analysed using single-antigen beads by One Lambda. We define an epitope as a set of amino acid positions that could account for the interaction of HLA alleles with anti-HLA antibodies. We call
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Autoimmune epitopes: autoepitopes
Autoimmunity Reviews, 2004The identity of reactants for autoantibodies has been successively refined from whole cellular organelles (immunofluorescence), identified molecules (immunoblot; gene expression libraries), epitope regions (truncated cDNAs; peptide scanning) to contact residues, as described here.
Ian R. Mackay, Merrill J. Rowley
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Methods of epitope mapping [PDF]
Molecular Biology Reports, 1992 It is important to remember that the merits of the different approaches to epitope mapping should be judged against the purpose of the study. A peptide specifically recognized by nearly all sera containing a certain autoimmune specificity [20, 21, 26], would most likely be selected for the detection of the anti-linear/continuous epitope fraction among ...
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Allergen structures and epitopes
Allergy, 2011To cite this article: Meno KH. Allergen structures and epitopes. Allergy 2011; 66 (Suppl. 95): 19–21.AbstractHuman type 1 hypersensitivity diseases such as allergic rhinoconjunctivitis are characterized by allergen‐specific IgE antibodies produced in allergic individuals after allergen exposure.
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Distinct epitopes on amiloride
American Journal of Physiology-Cell Physiology, 1989Most Na(+)-selective transport proteins are inhibited by the drug amiloride. Studies using amiloride analogues suggest that specific regions of amiloride might participate in binding to receptors on these transport proteins. To determine whether certain domains of this drug are recognized as distinct epitopes, amiloride was coupled to albumin through ...
David G. Warnock +4 more
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Epitope Peptides and Immunotherapy
Current Protein & Peptide Science, 2007Allergic diseases affect atopic individuals, who synthesize specific Immunoglobulins E (IgE) to environmental allergens, usually proteins or glycoproteins. These allergens include grass and tree pollens, indoor allergens such as house dust mites and animal dander, and various foods.
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Mapping the Epitopes of Antibodies
Biotechnology and Genetic Engineering Reviews, 2007(2007). Mapping the Epitopes of Antibodies. Biotechnology and Genetic Engineering Reviews: Vol. 24, No. 1, pp. 1-30.
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Seminars in Oncology, 2006
Variable expression of the HER2 receptor has been implicated in the pathogenesis of a number of malignancies. Many therapeutic modalities have been devised that target the receptor and downstream molecular pathways. The humanized monoclonal antibodies trastuzumab and pertuzumab bind epitopes on the extracellular domain, resulting in cell growth ...
Mark D. Pegram, Sumanta Kumar Pal
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Variable expression of the HER2 receptor has been implicated in the pathogenesis of a number of malignancies. Many therapeutic modalities have been devised that target the receptor and downstream molecular pathways. The humanized monoclonal antibodies trastuzumab and pertuzumab bind epitopes on the extracellular domain, resulting in cell growth ...
Mark D. Pegram, Sumanta Kumar Pal
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1991
By conventional immunological and physicochemical techniques natural allergens have been separated into antigenic and allergenic fractions. During the last years new methodological developments enabled to investigate their structures in detail. The first step was the identification of antigenic and allergenic (IgE-binding) epitopes on these molecules ...
W.-D. Müller +3 more
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By conventional immunological and physicochemical techniques natural allergens have been separated into antigenic and allergenic fractions. During the last years new methodological developments enabled to investigate their structures in detail. The first step was the identification of antigenic and allergenic (IgE-binding) epitopes on these molecules ...
W.-D. Müller +3 more
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T-cell epitopes of aeroallergens
Annals of Allergy, Asthma & Immunology, 2009To describe the current knowledge of the T-cell epitopes of common aeroallergens, how they were discovered, and implications for future therapy.PubMed search of English-language articles without date limits pertaining to T-cell epitopes of aeroallergens included on a standard skin test panel.A total of 127 articles were screened based on the results of
Adrian G. Letz, Christopher W. Calabria
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