Results 51 to 60 of about 6,357 (207)

Purification and Characterization of Recombinant Darbepoetin Alfa from Leishmania tarentolae [PDF]

, 2016
Darbepoetin alfa is a biopharmaceutical glycoprotein that stimulates erythropoiesis and is used to treat anemia, which associated with renal failure and cancer chemotherapy.
Ansari, J., Evazalipour, M., Kianmehr, A., Mahrooz, A., Oladnabi, M., Omidinia, E., Safdari, Y., Shahbazmohammadi, H., Veisi, K.   +8 more
core   +1 more source

Model‐Informed Drug Development for Daprodustat Supports the Design of Individualized Dosing Regimens in Chronic Kidney Disease Patients With Anemia

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 322-335, February 2026.
Model‐informed drug development (MIDD) played a crucial role in the successful development and regulatory approval of daprodustat, a novel oral hypoxia‐inducible factor prolyl hydroxylase (HIF‐PHI) inhibitor aimed at treating anemia in chronic kidney disease patients.
Kelly M. Mahar, Shuying Yang, Brendan Johnson, Sandra A.G. Visser, Paul van den Berg, Martijn van Noort, Teun M. Post   +6 more
wiley   +1 more source

HUMAN RECOMBINANT ERYTHROPOIETIN IN THE TREATMENT OF ANEMIA OF PATIENTS WITH CHRONIC RENAL FAILURE [PDF]

The Medical Journal of Basrah University, 2009
Objective: To compare the effect of small doses of recombinant erythropoietin on anemia of patients with chronic kidney disease who need dialysis and those are not on dialysis. Design: Case-comparative study.
Isam Hamo Mahmood, Emadeldin Ibrahim Al-badrani, Najlaa Saadi   +2 more
doaj   +1 more source

Neuroprotective properties of epoetin alfa [PDF]

Nephrology Dialysis Transplantation, 2002
Erythropoietin and its receptor function as primary mediators of the normal physiological response to hypoxia. Erythropoietin is recognized for its central role in erythropoiesis, but studies in which recombinant human erythropoietin (epoetin alfa) is injected directly into ischaemic rodent brain show that erythropoietin also mediates neuroprotection ...
Cerami, Anthony, Brines, Michael, Ghezzi, Pietro, Cerami, Carla, Itri, Loretta M   +4 more
openaire   +2 more sources

Darbepoetin alfa: An Effective Treatment with Flexible and Simplified Dosing for Anemia in Patients with Cancer [PDF]

, 2007
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90361/1/phco.27.3.434 ...
Natale, James J., Stevenson, James G.
core   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

CERA Detection and Stability in Blood Versus Urine

Drug Testing and Analysis, Volume 18, Issue 1, Page 16-23, January 2026.
This study presents comparative data on CERA detection in serum and urine samples, highlighting adverse analytical findings (AAFs) in serum that were undetected in corresponding urine samples. This shift would significantly improve the efficiency and sensitivity of CERA detection in doping control, ensuring more effective doping control programs ...
Olivier Salamin, Joséphine Chappuis, Lasse V. Bækken, Tiia Kuuranne, Nicolas Leuenberger   +4 more
wiley   +1 more source

Peran Eritropoietin pada Anemia Akibat Keganasan pada Anak

Sari Pediatri, 2016
Anemi relatif sering terjadi pada kasus keganasan hematologi atau tumor padat, namun penyebab anemia belum jelas diketahui. Eritropoietin merupakan suatu glikoprotein hormon yang dapat merangsang proliferasi dan diferensiasi sel-sel progenitor darah ...
Reni Suryanty, Nelly Rosdiana, Bidasari Lubis   +2 more
doaj   +1 more source

Implant Renal Injury‐Responsive Cells to Supplement Erythropoietin and Protect Kidney Injury

MedComm, Volume 6, Issue 11, November 2025.
Insufficient erythropoietin (EPO) production in injured kidneys leads to anemia and further exacerbates kidney damage. We constructed an injury‐responsive EPO‐producing (iREP) element that senses signals of kidney damage and drives the synthesis and secretion of native EPO.
Hao Nie, Chen Liang, Yingxin He, Siyu Wang, Xiaopeng Zhang, Jun Duan, Jieli Huang, Chen Yu, Yujia Wang, Zixian Zhao, Wei Zuo, Ting Zhang   +11 more
wiley   +1 more source

Rituximab therapy for pure red cell aplasia due to anti-epoetin antibodies in a woman treated with epoetin-alfa: a case report

Journal of Medical Case Reports, 2009
Introduction Pure red cell aplasia due to anti-epoetin antibodies is a known complication of epoetin therapy for anemia due to chronic kidney disease. This disease has not previously been well described in the setting of therapy for chronic hepatitis C ...
Behler Caroline M, Terrault Norah A, Etzell Joan E, Damon Lloyd E   +3 more
doaj   +1 more source