Results 1 to 10 of about 76 (54)

In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp. [PDF]

Molecules, 2021
Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol and have been shown to be promising drugs for Leishmaniases treatment.
Juliana Figueiredo Peixoto, Adriane da Silva Oliveira, Patrícia Queiroz Monteiro, Luiz Filipe Gonçalves-Oliveira, Valter Viana Andrade-Neto, Vitor Francisco Ferreira, Franklin Souza-Silva, Carlos Roberto Alves   +7 more
doaj   +6 more sources

Epoxy-α-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2H-naphtho[2,3-b]pyran-10,2′-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites [PDF]

Brazilian Journal of Infectious Diseases, 2023
Natural products and their derivatives have been sources of search and research for new drugs for the treatment of neglected diseases. Naphthoquinones, a special group of quinones, are products of natural metabolites with a wide spectrum of biological ...
Juliana Figueiredo Peixoto, Adriane da Silva Oliveira, Luiz Filipe Gonçalves - Oliveira, Franklin Souza - Silva, Carlos Roberto Alves   +4 more
doaj   +3 more sources

Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. [PDF]

Biomed Res Int, 2017
Leishmaniasis remains a serious public health problem in developing countries without effective control, whether by vaccination or chemotherapy. Part of the failure of leishmaniasis control is due to the lack of new less toxic and more effective drugs ...
Oliveira LFG, Souza-Silva F, Cysne-Finkelstein L, Rabelo K, Amorim JF, Azevedo AS, Bourguignon SC, Ferreira VF, Paes MV, Alves CR.   +9 more
europepmc   +6 more sources

The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Current treatment of cutaneous leishmaniasis includes pentavalent antimonials as first-line drugs, but this therapy has shown severe adverse effects. An alternative to minimize this issue is based on combination therapy scheme with other drugs.
Luiz Filipe Gonçalves-Oliveira, Ph.D., Franklin Souza-Silva, Ph.D., Luzia Monteiro de Castro Côrtes, Ph.D., Laura Barral Veloso, Ph.D., Bernardo Acácio Santini Pereira, Ph.D., Lea Cysne-Finkelstein, Ph.D., Guilherme Curty Lechuga, Ph.D., Saulo Cabral Bourguignon, Ph.D., Fernando Almeida-Souza, Ph.D., Kátia da Silva Calabrese, Ph.D., Vitor Francisco Ferreira, Ph.D., Carlos Roberto Alves, Ph.D.   +11 more
doaj   +4 more sources

Multifunctional nanoparticle for cancer therapy. [PDF]

MedComm (2020), 2023
Cancer is a complex disease associated with a combination of abnormal physiological processes affecting multiple systems. The single nanocarriers are not satisfy complex cancer diseases. However, multifunctional nanoparticles are upgraded versions of the original function and involve a sophisticated system with a proper backbone. Here, the construction
Gao Y, Wang K, Zhang J, Duan X, Sun Q, Men K.   +5 more
europepmc   +2 more sources

Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
Leishmaniasis is a disease caused by Leishmania spp., affecting millions of people around the world. For decades, its treatment has been based on pentavalent antimonials, which notoriously cause toxic side effects in patients.
Juliana Figueiredo Peixoto, Luiz Filipe Gonçalves-Oliveira, Franklin Souza-Silva, Luzia Monteiro de Castro Côrtes, Léa Cysne Finkelstein, Geovane Dias-Lopes, Beatriz Ferreira de Carvalho Patricio, Carolina Guimarães de Souza Lima, Helvécio Vinícius Antunes Rocha, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Bernardo Acácio Santini Pereira, Carlos Roberto Alves   +12 more
doaj   +2 more sources

Epoxy-α-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite. [PDF]

Antimicrob Agents Chemother, 2015
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Pós-Graduação em Ciências e Biotecnologia.
Souza-Silva F, Bourguignon SC, Pereira BA, Côrtes LM, de Oliveira LF, Henriques-Pons A, Finkelstein LC, Ferreira VF, Carneiro PF, de Pinho RT, Caffarena ER, Alves CR.   +11 more
europepmc   +2 more sources

Exploring 2D Graphene-Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective. [PDF]

Small Sci
Two‐dimensional graphene‐based nanomaterials are of significant interest in biomedical applications due to their unique physicochemical properties. Computational modeling provides useful insights into their structure and interactions with biological systems, aiding the nanoparticle design.
Kamboukos A, Todorova N, Yarovsky I.
europepmc   +2 more sources

African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment. [PDF]

Evid Based Complement Alternat Med, 2018
The use of traditional herbal remedies as alternative medicine plays an important role in Africa since it forms part of primary health care for treatment of various medical conditions, including wounds. Although physiological levels of free radicals are essential to the healing process, they are known to partly contribute to wound chronicity when in ...
Gulumian M, Yahaya ES, Steenkamp V.
europepmc   +2 more sources

Efficacy of Spironolactone Treatment in Murine Models of Cutaneous and Visceral Leishmaniasis [PDF]

, 2021
Translational studies involving the reuse and association of drugs are approaches that can result in higher success rates in the discovery and development of drugs for serious public health problems, including leishmaniasis.
Almeida-Amaral, Elmo Eduardo, Andrade-Neto, Valter Viana, Cunha-Junior, Edezio Ferreira, da Silva Pacheco, Juliana, Inácio, Job Domingos, Torres-Santos, Eduardo Caio   +5 more
core   +2 more sources