Epoxy-α-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2H-naphtho[2,3-b]pyran-10,2′-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites [PDF]
Brazilian Journal of Infectious Diseases, 2023 Natural products and their derivatives have been sources of search and research for new drugs for the treatment of neglected diseases. Naphthoquinones, a special group of quinones, are products of natural metabolites with a wide spectrum of biological ...
Juliana Figueiredo Peixoto +2 more
exaly +4 more sources
The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2019 Current treatment of cutaneous leishmaniasis includes pentavalent antimonials as first-line drugs, but this therapy has shown severe adverse effects. An alternative to minimize this issue is based on combination therapy scheme with other drugs.
Luiz Filipe Gonçalves-Oliveira +2 more
exaly +4 more sources
Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis [PDF]
International Journal for Parasitology: Drugs and Drug ResistanceLeishmaniasis is a disease caused by Leishmania spp., affecting millions of people around the world. For decades, its treatment has been based on pentavalent antimonials, which notoriously cause toxic side effects in patients.
Juliana Figueiredo Peixoto +2 more
exaly +4 more sources
In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp. [PDF]
Molecules, 2021 Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol and have been shown to be promising drugs for Leishmaniases treatment.
Juliana Figueiredo Peixoto +7 more
doaj +2 more sources
Multifunctional nanoparticle for cancer therapy. [PDF]
MedComm (2020), 2023 Cancer is a complex disease associated with a combination of abnormal physiological processes affecting multiple systems. The single nanocarriers are not satisfy complex cancer diseases. However, multifunctional nanoparticles are upgraded versions of the original function and involve a sophisticated system with a proper backbone. Here, the construction
Gao Y +5 more
europepmc +2 more sources
Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. [PDF]
Biomed Res Int, 2017 Leishmaniasis remains a serious public health problem in developing countries without effective control, whether by vaccination or chemotherapy. Part of the failure of leishmaniasis control is due to the lack of new less toxic and more effective drugs able to eliminate both the lesions and the parasite.
Oliveira LFG +9 more
europepmc +2 more sources
Exploring 2D Graphene-Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective. [PDF]
Small SciTwo‐dimensional graphene‐based nanomaterials are of significant interest in biomedical applications due to their unique physicochemical properties. Computational modeling provides useful insights into their structure and interactions with biological systems, aiding the nanoparticle design.
Kamboukos A, Todorova N, Yarovsky I.
europepmc +2 more sources
African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment. [PDF]
Evid Based Complement Alternat Med, 2018 The use of traditional herbal remedies as alternative medicine plays an important role in Africa since it forms part of primary health care for treatment of various medical conditions, including wounds. Although physiological levels of free radicals are essential to the healing process, they are known to partly contribute to wound chronicity when in ...
Gulumian M, Yahaya ES, Steenkamp V.
europepmc +2 more sources
Experimental and Molecular PathologyThe development of innovative treatments for American Cutaneous Leishmaniasis is crucial due to severe side effects of current treatment and the emergence of non-responder parasites.
Luiz Filipe Gonçalves-Oliveira +2 more
exaly +3 more sources
Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents. [PDF]
Pharmaceuticals (Basel), 2023 Tarasova EV +3 more
europepmc +1 more source