Results 151 to 160 of about 617,646 (369)

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

open access: yesAdvanced Science, EarlyView.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin   +15 more
wiley   +1 more source

A Versatile High‐Throughput Single‐Cell Screening Platform for Profiling Antigen‐Specific Long‐Lived B Cells in Blood and Bone Marrow

open access: yesAdvanced Science, EarlyView.
The MoSMAR‐chip platform provides a high‐throughput and cost‐effective tool for identifying and characterizing antigen‐specific antibody‐secreting cells (ASCs) and memory B cells (MBCs) at the single‐cell level. The ASCs from coronavirus disease 2019 (COVID‐19) vaccine‐immunized mice were successfully analyzed, revealing diverse neutralizing antibodies
Tian Zhao   +13 more
wiley   +1 more source

Silane and silazane surface modification of recycled glass fibers for polypropylene composites

open access: yesJournal of Applied Polymer Science, Volume 140, Issue 5, February 5, 2023., 2023
This study investigates the efficiency of multifunctional silane and silazane agents for surface modification of recycled glass fibers. Overall, the amino‐silane reagents improve the dispersion of GFs in PP, and permit subsequent reaction with MAPP leading to better compatibilization, with moderate improvements in strength attributed to the ...
Kyriaki Gkaliou, Anders E. Daugaard
wiley   +1 more source

Silicon Enhances Functional Mitochondrial Transfer to Improve Neurovascularization in Diabetic Bone Regeneration

open access: yesAdvanced Science, EarlyView.
These findings reveal that silicon exerts strong protective effects in diabetic bone defect models by selectively promoting Drp1‐Mff activity. Silicon facilitates precise regulation of mitochondrial dynamics to enable functional mitochondrial transfer.
Yu‐Xuan Ma   +12 more
wiley   +1 more source

Liquid Crystalline Self‐Assembly with Accelerated Kinetics and Higher Structural Orderliness in Centrifugal Acceleration Fields Beyond 7251 Times Gravity of Earth

open access: yesAdvanced Science, EarlyView.
How do chemical and physical processes involving multiple phases develop on compact astrophysical objects such as white dwarf stars? Herein, entropy‐driven self‐assembly of rod‐shaped nanoparticles in centrifugal acceleration fields up to 7251 times the gravity of Earth is investigated, where strong acceleration fields accelerated the kinetics of phase
Lingyan Xu, Hongbo Zhao, Pei‐Xi Wang
wiley   +1 more source

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

open access: yesAdvanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen   +9 more
wiley   +1 more source

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