Results 211 to 220 of about 87,071 (315)

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu   +6 more
wiley   +1 more source

Investigations of toughening mechanisms of epoxy resins [PDF]

open access: yes
Composite material technology was applied to the solid rocket booster by the development of a carbon filament-epoxy resin case which yields a net increase of 4000 lbs. in payload in the shuttle.
Koenig, T.
core   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

open access: yesAdvanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira   +18 more
wiley   +1 more source

Solar‐Powered Electrokinetic Filtration using Hierarchical Porous Membranes for the Off‐Grid Removal of Ultrafine Contaminants

open access: yesAdvanced Science, EarlyView.
A solar‐powered nanoelectrokinetic filtration system enables high‐flux removal of ultrafine contaminants without relying on nanoscale pores or pressure‐driven membranes, offering a sustainable solution for the off‐grid water purification. Abstract The removal of ultrafine suspended solids from water remains a critical challenge due to the tradeoffs ...
Woonjae Choi   +4 more
wiley   +1 more source

Novel Bio-Based Materials: From Castor Oil to Epoxy Resins for Engineering Applications. [PDF]

open access: yesMaterials (Basel), 2023
Gaina C   +4 more
europepmc   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

open access: yesAdvanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta   +14 more
wiley   +1 more source

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