Results 131 to 140 of about 947,323 (274)

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Tailoring drug‐to‐lipid ratio in redox‐responsive lipid‐mimetic prodrug liposomes for superior cabazitaxel delivery and antitumor efficacy

BMEMat, EarlyView.
Redox‐responsive lipid‐mimetic prodrug liposomes with high drug‐to‐lipid ratios enhance cabazitaxel delivery, prolong circulation, and enable tumor‐selective drug release for superior antitumor efficacy and safety. Abstract Liposomes represent one of the most extensively investigated nanocarriers in drug delivery.
Shengyao Xu, Danping Wang, Si Zheng, Zhiyu Kuang, Ya Gao, Haiyu Zhao, Lurong Zhang, Jiayu Guo, Jingyi Zhang, Weiyao Li, Anhua Wang, Hongrui Lei, Zhonggui He, Ken‐ichiro Kamei, Jianzhao Niu, Lingyun Ma, Bingjun Sun   +16 more
wiley   +1 more source

Improving the Treatment of Brain Gliomas Through Small-Particle-Size Paclitaxel-Loaded Micelles with a High Safety Profile

Pharmaceutics
Background/Objectives: Paclitaxel (PTX) is widely used in the treatment of a variety of solid tumours due to its broad-spectrum anti-tumour activity, but its use in brain gliomas is limited by insufficient blood–brain tumour barrier (BBTB) penetration ...
Bohan Chen, Liming Gong, Jing Feng, MongHsiu Song, Mingji Jin, Liqing Chen, Zhonggao Gao, Wei Huang   +7 more
doaj   +1 more source

Combining the Spin-Trap Methodology with EPR Spectroscopy to Investigate the Antioxidant Activity of Beer

openQuesto esperimento di laboratorio utilizza un'esplorazione della stabilità allo stoccaggio della birra per introdurre aspetti fondamentali della spettroscopia a risonanza paramagnetica elettronica (EPR).
SOVILLA, ANDREA
core  

A bioinspired catalytic nanoplatform for ferroptosis‐immunotherapy synergy in metastatic cancer

BMEMat, EarlyView.
The bioinspired nanoplatform MnMSN@MnP‐PEG co‐delivers manganese peroxidase and manganese ions to synergistically induce immunogenic ferroptosis and activate the cGAS‐STING pathway, eliciting potent antitumor immunity against primary and metastatic tumors.
Panpan Xue, Hai Cai, Ying Sun, Yaxin Ma, Siyuan Liu, Jinying Zhu, Yan Chen, Xuemei Zeng, Shuangqian Yan   +8 more
wiley   +1 more source

Detoxification of hydrogen sulfide by synthetic heme model compounds

Scientific Reports
Hydrogen sulfide is a lethal toxic gas that disrupts cellular respiration in the mitochondrial system. Currently, no antidote is available for the clinical treatment of hydrogen sulfide poisoning.
Atsuki Nakagami, Qiyue Mao, Masaki Horitani, Masahito Kodera, Hiroaki Kitagishi   +4 more
doaj   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Axial Solvent Coordination in “Base-Off” Cob(II)alamin and Related Co(II)-Corrinates Revealed by 2D-EPR

, 2016
Detailed information on the structure of cobalt(II) corrinates is of interest in the context of studies on the coenzyme B12 catalyzed enzymatic reactions, where cob(II)alamin has been identified as a reaction intermediate.
Rüdiger-Albert Eichel (2523373), Bernhard Kräutler (461445), Daniella Goldfarb (1262241), Arthur Schweiger (2268661), Sabine Van Doorslaer (175514), Boris Epel (2172082), Gunnar Jeschke (1268802)   +6 more
core   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Channel‐trap coupled charge modulation in sulfur‐vacancy‐rich nanotransducer for enhanced dual‐mode cancer catalytic therapy

BMEMat, EarlyView.
Sulfur vacancy‐rich ZnS–NCx heterojunctions are engineered as dual‐function nanotransducers, in which channel‐trap‐coupled electronic pathways enable efficient capture and transport of ultrasound‐induced piezoelectrons. This vacancy‐mediated regulation simultaneously enhances sonodynamic activity and biomimetic POD/GSHOx catalysis, triggering a self ...
Songjing Zhong, Zeyu Zhang, Wenting Chen, Quanhong Hu, Hongyi Sun, Ruidong Yin, Qinyu Zhao, Hongbo Fan, Yuanbo Cui, Yuxuan Zhang, Linlin Li   +10 more
wiley   +1 more source