Results 101 to 110 of about 5,685 (219)

Modulação das respostas de activação plaquetária pelo eptifibatide: uma abordagem citómica e proteómica [PDF]

, 2011
Os antiplaquetários são actualmente bastante utilizados no controlo das doenças cardiovasculares, a principal causa de morte no mundo ocidental.
Andrade, Cláudia Sofia Coutinho
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Fmoc Solid-phase Synthesis and Purification of Eptifibatide

, 2007
Eptifibatide是一种血小板糖蛋白GPⅡb/Ⅲa受体拮抗剂,临床研究结果显示其医用上的产业前景良好.采用Rink-Am-Resin树脂作为固相载体,Fmoc为保护策略固相合成了Eptifibatide.以DMF为反应溶剂,Piperidine-DMF脱去Fmoc保护基团,以TBTU/HOBt/DIEA作为肽键缩合试剂进行接肽反应,用TFA/EDT/TIS/H2O定量地从树脂上切除,制备型高效液相色谱分离纯化粗肽.同时对产品进行色谱分析和质谱鉴定.实验结果表明Fmoc合成策略中各步的缩合率均在95%
王宇, 陈亮, 熊瑛
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Platelet anesthesia with nitric oxide with or without eptifibatide during cardiopulmonary bypass in baboons

, 1999
Objective:This study tested the hypothesis that nitric oxide or nitric oxide and eptifibatide (Integrilin) reversibly inhibit platelet activation and consumption during cardiopulmonary bypass and rapidly restore platelet numbers and function after bypass.
Hanson, C.William, Malekan, Ramin, Sun, Ling, Rao, A.Koneti, Niewiarowski, Stefan, Edmunds, L.Henry, Suzuki, Yasuyuki   +6 more
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Significance of shear and dose for eptifibatide as judged by MANOVA with Tukey's Posttest.

, 2014
Significance of shear and dose for eptifibatide as judged by MANOVA with Tukey's Posttest.
Melissa Li (505693), Craig R. Forest (505696), Nathan A. Hotaling (505694), David N. Ku (505695)   +3 more
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Investigation of interaction of human platelet membrane components with anticoagulant drugs Abciximab and Eptifibatide

Folia Histochemica et Cytobiologica, 2010
Abciximab (Abci) and eptifibatide (Epti) are antiaggregate drugs which may reduce thrombotic complications inacute coronary syndromes. The aim of this work was the investigation of the interaction between the phospholipid-GPIIb/IIIa glycoprotein complex ...
Ewa Gorodkiewicz, Anna Sankiewicz, Zbigniew A. Figaszewski   +2 more
doaj  

Abbreviated Infusion of Eptifibatide After Successful Coronary Intervention The BRIEF-PCI (Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention) Randomized Trial

, 2009
ObjectivesThe purpose of this study was to assess whether the early discontinuation of eptifibatide infusion in nonemergent percutaneous coronary intervention (PCI) is associated with a higher frequency of periprocedural ischemic myonecrosis ...
Fung, Anthony Y., Fox, Rebecca S., Ricci, Donald R., Buller, Christopher E., Webb, John G., Humphries, Karin H., Starovoytov, Andrew, Aymong, Eve, Jokhi, Percy, Walsh, Simon J., Carere, Ronald G., Densem, Cameron, Hamburger, Jaap N., Saw, Jacqueline   +13 more
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Modifiable Risk Factors for Vascular Access Site Complications in the IMPACT II Trial of Angioplasty With Versus Without Eptifibatide

, 1998
Objectives. This study was designed to identify potential predictors of vascular access site (VAS) complications in the large-scale Integrilin to Minimize Platelet Aggregation and Coronary Thrombosis (IMPACT) II trial, which studied angioplasty with ...
Blankenship, James C., Timmis, Gerald C., Gerald C. Timmis, Resar, Jon, Talley, J.David, Gardner, Laura H., Berkowitz, Scott D., Frank V. Aguirre, Aguirre, Frank V., Gilchrist, Ian C., Topol, Eric J., Mandak, Jeffrey S., Weiner, Bonnie H., Kristina N. Sigmon, A.Michael Lincoff, Jon Resar, Scott D. Berkowitz, Tcheng, James E., Sigmon, Kristina N., Jeffrey S. Mandak, Lincoff, A.Michael, James E. Tcheng, Robert M. Califf, George, Barry S., Barry S. George, Califf, Robert M., James C. Blankenship, Bonnie H. Weiner, McIvor, Michael, J.David Talley, Laura H. Gardner, Michael McIvor, Eric J. Topol, Ian C. Gilchrist   +33 more
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Eptifibatide reduces septic platelet-induced splenocyte apoptosis ex vivo.

, 2013
A. Representative flow cytometry staining of CD4+ splenocytes for pan-caspase FLICA (Y axis) vs. TUNEL (X axis) in presence of (left-to-right) no platelets, septic platelets, septic platelets with anti-62P antibody, or septic platelets with eptifibatide.
Angela S. Benton (314055), Lindsay M. Garvin (314053), Matthew Sharron (314050), Kanneboyina Nagaraju (241056), Robert J. Freishtat (314056), Andrew A. Wiles (314052), Mayya Geha (314054), Claire E. Hoptay (314051)   +7 more
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Eptifibatide provides additional platelet inhibition in Non–ST-Elevation myocardial infarction patients already treated with aspirin and clopidogrel Results of the platelet activity extinction in Non–Q-Wave myocardial infarction with aspirin, clopidogrel, and eptifibatide (PEACE) study

, 2004
ObjectivesThe present study hypothesis was that eptifibatide offered further antiplatelet efficacy above clopidogrel in non–ST-elevation myocardial infarction (NSTEMI) patients before an expeditive coronary intervention.BackgroundAlthough thienopyridines
Sollier, Claire Bal dit, Choussat, Rémi, Montalescot, Gilles, Gallois, Vanessa, Drouet, Ludovic, Collet, Jean-Philippe, Dalby, Miles, Soulat, Thierry, Vicaut, Eric, Drobinski, Gérard, Thomas, Daniel   +10 more
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Administration of eptifibatide during endovascular treatment of ruptured cerebral aneurysms reduces the rate of thromboembolic events

, 2015
International audienceIntroduction Thromboembolic complications are the most frequent complications of endovascular treatment of ruptured intracranial aneurysms.
Suissa, Laurent, Sedat, Jacques, Chau, Yves, Lachaud, Sylvain, Gaudard, Jean, Lonjon, Michel   +5 more
core   +1 more source