Results 231 to 240 of about 8,424 (263)

Abstract WP25: Eptifibatide in Acute Ischemic Strokes Without Large Vessel Occlusions

Stroke
Background: Platelet glycoprotein IIb/IIIa inhibitors are currently being researched for patients with acute ischemic stroke (AIS), however there is no consensus on which inhibitor or dose is both safe and effective.
Subutay B. Bozkurt, Yong-Bum Song, Joshua Haimi, S. Sahito, Muhammad Nabeel Akbar, Paul Fanous, Ibrahim Abualnadi, Abdallah O Amireh, Michael Gates, Marriam Malik, Mariah Siddiqui, Nicholas Briski, sarah Abdelmessih, Yasemin Akinci, Kiapour Nazanin, Hubashia Khan, Nancy E Gadallah, N. Tabibzadeh, Sara Strauss, Arifa Ghori, S. Scarpiello, Thomas Snyder   +21 more
semanticscholar   +1 more source

Acute Profound Thrombocytopenia Associated with Eptifibatide Therapy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2003
An 80‐year‐old woman and a 79‐year‐old man underwent urgent percutaneous coronary intervention and received adjunctive eptifibatide. Platelet counts in both patients fell to below 20 times 103/mm3 within 4 hours of eptifibatide administration. Reports in the medical literature reinforce the importance of recognizing that eptifibatide can cause acute ...
Cynthia A. Jackevicius, Cynthia A. Jackevicius, Cynthia A. Jackevicius, Peter H. Seidelin, Jeff Nagge, John R. Ross, Vladimir Dzavik, Vladimir Dzavik   +7 more
openaire   +3 more sources

Eptifibatide-Induced Thrombocytopenia and Subsequent Thrombosis

Journal of Pharmacy Technology, 2012
Objective: To report a case of thrombocytopenia and thrombosis associated with the administration of eptifibatide. Case Summary: We describe the case of a 63-year-old male who developed thrombocytopenia and thrombosis associated with eptifibatide administration. Eptifibatide (2 μg/kg/min, following a 180-μg/kg bolus) was administered on hospital day 5,
Hani Kador, Christopher Giuliano, Marjorie Mooney, Stephanie B. Edwin   +3 more
openaire   +2 more sources

Abstract WP16: ROLE OF EPTIFIBATIDE IN POST-THROMBECTOMY STENOSIS

Stroke
Introduction: Currently, no level A evidence exists for the optimal rescue strategy for cases at high risk for re-occlusion following endovascular thrombectomy (EVT) in acute ischemic stroke.
Sivani Lingam, William Liu, Sabriya Sowers, Margaret Houghton, Laith N Maali   +4 more
semanticscholar   +1 more source

Severe thrombocytopenia possibly related to readministration of eptifibatide

Catheterization and Cardiovascular Interventions, 2001
AbstractThrombocytopenia following eptifibatide therapy is a rare event, and acute severe thrombocytopenia following readministration has not been reported. We describe a case of acute severe thrombocytopenia following reexposure to eptifibatide during percutaneous coronary intervention.
Susan Hurden, Fran L. Paradiso-Hardy, Mina Madan, Sam Radhakrishnan, Eric A. Cohen   +4 more
openaire   +3 more sources

Intracoronary delivery of eptifibatide with the ClearWay® RX infusion catheter

Catheterization and Cardiovascular Interventions, 2011
AbstractAcute coronary syndromes are caused by plaque rupture and the formation of an occlusive thrombus. Intracoronary (IC) bolus administration of eptifibatide may result in higher levels of platelet glycoprotein IIb/IIIa (GP IIb/IIIa) receptor occupancy (RO) in the local coronary bed, disaggregate thrombus in the epicardial artery, and ...
C. Michael Gibson, Albert J. Deibele
openaire   +3 more sources

Impact of computerized dosing on eptifibatide-associated bleeding and mortality

American Heart Journal, 2009
The study aimed to determine the impact on eptifibatide-associated bleeding by implementing a computerized dosing algorithm in the cardiac catheterization suite.Excessive dosing of eptifibatide is associated with increased bleeding rates and hospital mortality. Although dosing adjustments based on renal function has been recommended, its implementation
John M. Buergler, David Putney, Robert E. Fromm, Neal S. Kleiman   +3 more
openaire   +3 more sources

Characterization of eptifibatide during drug formulation stability assays

Journal of Pharmaceutical and Biomedical Analysis, 2003
The objective of the study was to determine the identity of a new impurity detected in HPLC chromatograms of research samples of eptifibatide manufactured by a new process and formulated into drug product. The identification of the unknown impurity was required in order to understand the mechanism of its formation.
Ronghua Wang, Debby Feder, Frank Y. Hsieh   +2 more
openaire   +3 more sources

PEGylated PAMAM Dendrimers as Eptifibatide Nanocarriers: An Atomistic View from Molecular Dynamics Simulations

Chemical Engineering and Science, 2022
Farideh Badalkhani-Khamseh, A. Ebrahim-Habibi, N. Hadipour, M. Behmanesh   +3 more
semanticscholar   +1 more source

Efficacy outcomes and safety measures of intravenous tirofiban or eptifibatide for patients with acute ischemic stroke: a systematic review and meta-analysis of prospective studies

Journal of Thrombosis and Thrombolysis, 2021
Jingting Liu, Yihong Yang, Hongbo Liu
semanticscholar   +1 more source