Results 271 to 280 of about 46,677 (295)

Genome-wide association and gene-virus interaction study of liver disease in hepatitis C virus-infected patients

Quistrebert J, Chai H, Chen Y, Ramamurthy N, Innes H, Benselin J, Wang Z, Shen Q, Marchi E, Pedergnana V, Klenerman P, Cooke G, Barnes E, Irving WL, McLauchlan J, Ansari MA.   +15 more
europepmc   +1 more source

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Nature Genetics, 2021
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) analyses using ...
Urmo Võsa, Annique A J Claringbould, Harm-Jan Westra   +2 more
exaly   +2 more sources

Single-cell eQTL models reveal dynamic T cell state dependence of disease loci

Nature, 2022
Aparna Nathan, Samira Asgari, Kazuyoshi Ishigaki   +2 more
exaly   +2 more sources

Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits

Nature Genetics, 2022
Biao Zeng, Jaroslav Bendl, John F Fullard   +2 more
exaly   +2 more sources

Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants

Science Immunology, 2022
The impact of genetic variants on cells challenged in biologically relevant contexts has not been fully explored. Here, we activated CD4+ T cells from 89 healthy donors and performed a single-cell RNA sequencing assay with >1 million cells to examine ...
Benjamin J Schmiedel, Cristian Gonzalez-Colin, Vicente Fajardo   +2 more
exaly   +2 more sources

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

Nature Genetics, 2016
Zhihong Zhu, , Han Hu
exaly   +2 more sources

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Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease

Science, 2022
The human immune system displays substantial variation between individuals, leading to differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing (scRNA-seq) data from 1,267,758 peripheral blood mononuclear cells from 982 ...
S. Yazar, José Alquicira-Hernández, Kristof Wing, A. Senabouth, M. G. Gordon, Stacey B. Andersen, Qinyi Lu, Antonia Rowson, Thomas R. P. Taylor, Linda Clarke, Katia Maccora, Christine Y. Chen, A. Cook, Chun Jimmie Ye, K. Fairfax, A. Hewitt, J. Powell   +16 more
semanticscholar   +1 more source

Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

Nature Genetics, 2019
Genome-wide association studies (GWAS) have identified genetic variants at 34 loci contributing to age-related macular degeneration (AMD)1–3. We generated transcriptional profiles of postmortem retinas from 453 controls and cases at distinct stages of ...
Rinki Ratnapriya, Olukayode A Sosina, Margaret R Starostik   +2 more
exaly   +2 more sources

Combined GWAS and eQTL analysis uncovers a genetic regulatory network orchestrating the initiation of secondary cell wall development in cotton

New Phytologist, 2020
The cotton fiber serves as a valuable experimental system to study cell wall synthesis in plants, but our understanding of the genetic regulation of this process during fiber development remains limited. We performed a genome-wide association study (GWAS)
Xiangnan Zhang, Chao Shen, Gregory N Thyssen   +2 more
exaly   +2 more sources

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Scientific Data, 2020
The availability of high-quality RNA-sequencing and genotyping data of post-mortem brain collections from consortia such as CommonMind Consortium (CMC) and the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) Consortium enable the ...
Solveig K Sieberts, Minerva M Carrasquillo, Joseph S Reddy   +2 more
exaly   +2 more sources