Results 51 to 60 of about 1,524,763 (305)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Bias-Adjusted Treatment Effects Under Equal Selection
, 2021 In a recent contribution, Oster (2019) has proposed a method to generate bounds on treatment effects in the presence of unobservable confounders. The method can only be implemented if a crucial problem of non-uniqueness is addressed.
Basu, Deepankar
core +1 more source
Alman Federal İş Mahkemesi'nin 2 AZR 596/20 No’lu ve 20 Mayıs 2021 Tarihli Kararı
Türk-Alman Üniversitesi Hukuk Fakültesi Dergisi, 2022 Kişinin Kimin Önünde ve Hangi Durumda Kıyafetini Çıkaracağına Karar Verme Hakkını Hiçe Sayarak İşyerinde Cinsel Organının Ortaya Çıkarılmasının Genel Eşit Muamele Kanunu'nun (AGG) 3. Maddesi 4.
Pelin Kurşat
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
, 2020 In her papers “No Exception for Belief” and “Equal Treatment for Belief”, Susanna Rinard defends a view she calls “Equal Treatment” (ET).1 ET is the thesis that, “whatever general principles govern what one ...
Britt, Kieran
core +1 more source
Límites a la libre circulación de los beneficiarios de protección subsidiaria
European Papers, 2016 (Series Information) European Papers - A Journal on Law and Integration, 2016 1(1), 193-202 | European Forum Insight of 16 April 2016 | (Table of Contents) I. Introducción. - II. ¿Incluye el concepto de libre circulación recogido en el art.
Gloria Fernández Arribas
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source