Results 71 to 80 of about 163,152 (265)

Pathways between childhood trauma, intimate partner violence, and harsh parenting: findings from the UN Multi-country Study on Men and Violence in Asia and the Pacific

The Lancet Global Health, 2017
Summary: Background: Although childhood trauma and violence against women are global public health issues, few population-based data from low-income and middle-income countries exist about the links between them.
Emma Fulu, DrPhD, Stephanie Miedema, MA, Tim Roselli, BSc, Sarah McCook, MA, Ko Ling Chan, PhD, Regine Haardörfer, PhD, Rachel Jewkes, ProfMBBS MD, Emma Fulu, Rachel Jewkes, Xian Warner, Stephanie Miedema, Tim Roselli, James Lang, Ruchira Tabassum Naved, Hamidul Huque, Subrina Farah, Muhammad Mizanur Rashid Shuvra, Arthur Erken, Wang Xiangxian, Fang Gang, Li Hongtao, Zeljka Mudrovcic, Wen Hua, Arie Hoekman, Elina Nikulainen, Bernard Coquelin, Mariam Khan, Wenny Kusuma, Clara Magariño Manero, Freya Larsen, Emma Fulu, Xian Warner, Saba Moussavi, Neloufer de Mel, Pradeep Peiris, Shyamala Gomez, Social Indicator Team, Kamani Jinadasa, Rachel Jewkes, Yandisa Sikweyiya, Nwabisa Shai, Francesca Drapuluvik-Tinabar, Peterson Magoola, Anthony Agyenta, Thomas Shanahan, Tracy Vienings, Rachel Jewkes, Claudia Garcia-Moreno, Ruchira Tabassum Naved, Kamani Jinadasa, Tracy Vienings, Wenny Kusuma, Rachel Jewkes, Raewyn Connell, Gary Barker, Alan Greig, Rahul Roy, Ravi Verma, Kalyani Menon Sen, Scott Johnson   +59 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Competing framings of abortion access reform campaigns in Madagascar: barriers to effective coalition building

Frontiers in Reproductive Health
In sub-Saharan Africa, civil society organisations have a key role in putting abortion law and policy reform on the political agenda, and mobilising opinion in favour of such reform.
Mina H. Rakotoarindrasata, Eugene Andriamasy, Tamaryn L. Crankshaw, Jane Freedman   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source