Results 101 to 110 of about 88,462 (295)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Academic standards and gender equality

Educar
This paper provides an analysis of gender equality at the Faculty of Arts of the University of Ljubljana and examines the main results in the broader context of quality in higher education.
Živa Kos, Jasna Mažgon, Milica Antić Gaber   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Gender Equality Plan at the University of Ljubljana: The Case of Work–Life Balance

Social Inclusion
The article addresses the challenges to achieving gender equality in academia, with a particular focus on work–life balance as outlined in the University of Ljubljana’s Gender Equality Plan (2022–2027).
Alenka Švab, Vesna Leskošek, Andreja Živoder   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Bandwidth Depletion

The Measures for Advancing Gender Equality (MAGNET) initiative aims to broaden and deepen the measurement of women’s agency, based on the development of new tools and rigorous testing and comparison of both new and existing methods for measuring agency ...
Measures for Advancing Gender Equality (MAGNET) Initiative
core   +2 more sources

Cognitive Labor

The Measures for Advancing Gender Equality (MAGNET) initiative aims to broaden and deepen the measurement of women’s agency, based on the development of new tools and rigorous testing and comparison of both new and existing methods for measuring agency ...
Measures for Advancing Gender Equality (MAGNET) Initiative
core   +2 more sources

Study on the role of men in gender equality

, 2013
Gender relations have increasingly changed throughout the past decades, and European gender politics have productively accompanied these improvements. Still Europe is far from being a gender-equal society.
White, Alan, Schuck, Hartwig, Scambor, Christian, Hearn, Jeff, Hrženjak, Majda, Scambor, Elli, Belghiti-Mahut, Sophia,, Wojnicka, Katarzyna,, Scambor, Elli,, Holter, Øystein Gullvåg,, Belghiti-Mahut, Sophia, Puchert, Ralf, Scambor, Christian,, Seidler, Victor, Bergmann, Nadja,, Schuck, Hartwig,, White, Alan,, Holter, Øystein Gullvåg, Gärtner, Marc,, Gullvåg Holter, Øystein, Bergmann, Nadja, Hearn, Jeff,, Puchert, Ralf,, Wojnicka, Katarzyna, Hrženjak, Majda,, Gärtner, Marc, Seidler, Victor,   +26 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source