Results 91 to 100 of about 37,104 (259)

Olfactory‐to‐Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency‐Specific Oscillatory Decoupling

open access: yesAdvanced Science, EarlyView.
Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang   +13 more
wiley   +1 more source

A Novel Structure and Detection for Double-Layer Bit-Patterned Media Recording

open access: yesIEEE Access
With the rapid growth of data volumes, the demand for high-capacity storage systems continues to rise. To address this challenge, double-layer bit-patterned media recording (DLBPMR), a combination of double-layer magnetic recording (DLMR) and bit ...
Thien An Nguyen   +2 more
doaj   +1 more source

Equalization of Legal Status with Respect to Gender

open access: diamond, 2016
Nadezhda N. Tarusina   +1 more
openalex   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu   +11 more
wiley   +1 more source

A Power Transistor Active Gate Driver With Two-Level Miller Plateau Detection and Driving Device Equalization Using 180-nm HV BCD Process

open access: yesIEEE Open Journal of Circuits and Systems
The configuration of the active gate driver (AGD) significantly impacts how well power semiconductor devices work and how efficient they are. This research presents a new AGD single chip design that identifies the Miller plateau when the signal is ...
Chua-Chin Wang   +6 more
doaj   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

open access: yesAdvanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao   +19 more
wiley   +1 more source

Effect of Perforated Inlet Structure on Thermodynamic Characteristics of Hot Water Storage Tank

open access: yesZhileng xuebao, 2018
Heat storage technique is important to solar thermal energy utilization. Furthermore, it a key technology that uses water as a thermal storage medium.
Huang Huajie   +4 more
doaj  

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

open access: yesAdvanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei   +10 more
wiley   +1 more source

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