Results 131 to 140 of about 737,010 (261)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Equation of State for Europium at High Pressures and Entropies in Shock Waves. [PDF]

Materials (Basel)
Khishchenko KV.
europepmc   +1 more source

New Alpha Functions for the Peng-Robinson Cubic Equation of State. [PDF]

ACS Omega, 2022
Sun X, Fang Y, Zhao W, Xiang S.
europepmc   +1 more source

A NEW EQUATION OF STATE [PDF]

Proceedings of the National Academy of Sciences, 1929
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Prediction of Phase Equilibria of Polycyclic Aromatic Hydrocarbons in Organic Solvents with the SAFT‑γ Mie Equation of State. [PDF]

Ind Eng Chem Res
Bernet T, Paliwal S, Tan BI, Haslam AJ, Adjiman CS, Jackson G, Galindo A.   +6 more
europepmc   +1 more source

Numerical investigation on acoustic cavitation characteristics of an air-vapor bubble: Effect of equation of state for interior gases. [PDF]

Ultrason Sonochem, 2023
Qin D, Lei S, Chen B, Li Z, Wang W, Ji X.   +5 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Classical Density Functional Theory Coupled to the SAFT-VR Mie Equation of State: Extension to Associating Fluids. [PDF]

J Phys Chem B
de Freitas Gonçalves A, Barros de Souza N, Fernando Mercier Franco L.   +2 more
europepmc   +1 more source

Combined Description of the Equation of State and Diffusion Coefficient of Liquid Water Using a Two-State Sanchez-Lacombe Approach. [PDF]

Molecules, 2023
Ginzburg VV, Fazio E, Corsaro C.
europepmc   +1 more source