Results 81 to 90 of about 4,347,679 (285)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Development of a predictive equation for resting energy expenditure in pediatric patients with oncological diagnosis

Frontiers in Nutrition
Background and aimPediatric cancer is a significant health concern, particularly in low- and middle-income countries with lower cure rates. The nutritional status of these patients is crucial because malnutrition, whether due to a deficiency or excess of
Alda Daniela García-Guzmán, Alda Daniela García-Guzmán, Sandra Nayeli Becerra-Morales, Sandra Nayeli Becerra-Morales, Beatriz Adriana Pinzón-Navarro, Beatriz Adriana Pinzón-Navarro, Daffne Danae Baldwin-Monroy, Daffne Danae Baldwin-Monroy, Daffne Danae Baldwin-Monroy, Daffne Danae Baldwin-Monroy, Daffne Danae Baldwin-Monroy, Marta Zapata-Tarres, Liliana Velasco-Hidalgo, Liliana Velasco-Hidalgo, Azalia Avila-Nava, Rocío del Socorro Cárdenas-Cardos, Karla Maldonado-Silva, Martha Guevara-Cruz, Martha Guevara-Cruz, Isabel Medina-Vera, Isabel Medina-Vera   +20 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Validation of a Novel, Sex-Specific LDL-Cholesterol Equation and the Friedewald, Sampson-NIH, and Extended-Martin–Hopkins Equations Against Direct Measurement in Korean Adults

Metabolites
Background/Objectives: The currently established equations for calculating low-density lipoprotein cholesterol (LDLc) do not reflect the sex-specific differences in lipid metabolism. We aimed to develop a sex-specific LDLc equation (SSLE) and validate it
Hyun Suk Yang, Soo-Nyung Kim, Seungho Lee, Mina Hur   +3 more
doaj   +1 more source

Mass balancing for coal processing plant design [PDF]

MATEC Web of Conferences
With the advent of modern mass balancing programmes, the roots of what makes up these programmes are being lost to all but the developers. This paper draws on the author's experience of designing coal processing plants whilst straddling the transition ...
Cresswell Mark
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Efeitos de indicadores e dias de coleta na digestibilidade dos nutrientes e nas estimativas do valor energético de alimentos para vacas alimentadas com diferentes fontes de proteína Comparison of internal markers and extent of total fecal collection to estimate nutrient digestibility and energy value of feeds on dairy cows fed different protein sources

Revista Brasileira de Zootecnia, 2006
Foram utilizadas 12 vacas da raça Holandesa, entre puras e mestiças, distribuídas em três quadrados latinos 4 x 4, organizados de acordo com os dias em lactação, com o objetivo de avaliar o efeito de dois períodos de coleta de fezes (dois ou seis dias ...
Douglas dos Santos Pina, Sebastião de Campos Valadares Filho, Edenio Detmann, Rilene Ferreira Diniz Valadares, José Maurício de Souza Campos, Kamila Andreatta Kling de Moraes, André Soares de Oliveira, Mônica Lopes Paixão   +7 more
doaj   +1 more source