Results 31 to 40 of about 6,532,257 (294)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Neural correlates of vestibular adaptation in cosmonauts after long duration spaceflight

npj Microgravity
Long-duration spaceflight affects otolith-mediated ocular counter-roll (OCR) and brain function, but the relationship between these changes is unclear.
Catho Schoenmaekers, Steven Jillings, Sepehr Mortaheb, Dmitrii Glukhikh, Ivan Naumov, Elena Tomilovskaya, Ilya Rukavishnikov, Ekaterina Pechenkova, Alexandra Ryabova, Lyudmila Makovskaya, Inna Nosikova, Peter zu Eulenburg, Floris L. Wuyts   +12 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Solving Split Pseudomonotone Equilibrium Problems with Multiple Output Sets: Applications in Machine Learning for Medical Diagnosis

Axioms
We introduce a new class of split inverse problems, termed the Split Pseudomonotone Equilibrium Problem with Multiple Output Sets, which generalizes classical equilibrium formulations to accommodate multiple decision outputs and pseudomonotonicity.
Olaniyi S. Iyiola, Amara R. Eze, Timilehin O. Alakoya, Oluwatosin T. Mewomo, Wisdom Attipoe   +4 more
doaj   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Physiological cerebrospinal fluid interactions between brain and eye structures are altered after long‐duration spaceflight

Experimental Physiology
Long‐duration spaceflight represents an extreme challenge, triggering adaptive responses including spaceflight‐associated neuro‐ocular syndrome, characterized by diminished visual acuity and ocular changes, which is a significant health risk for Mars ...
Ge Tang, Steven Jillings, Ben Jeurissen, Elena Tomilovskaya, Inna Nosikova, Alexandra Ryabova, Ekaterina Pechenkova, Viktor Petrovichev, Ilya Rukavishnikov, Stefan Sunaert, Paul M. Parizel, Lyudmila Makovskaya, Valentin Sinitsyn, Jan Sijbers, Jitka Annen, Steven Laureys, Angelique Van Ombergen, Seyed‐Ahmad Ahmadi, Floris L. Wuyts, Peter zu Eulenburg   +19 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

The Augmented Weak Sharpness of Solution Sets in Equilibrium Problems

Mathematics
This study considers equilibrium problems, focusing on identifying finite solutions for feasible solution sequences. We introduce an innovative extension of the weak sharp minimum concept from convex programming to equilibrium problems, coining this as ...
Ruyu Wang, Wenling Zhao, Daojin Song, Yaozhong Hu   +3 more
doaj   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source