Results 41 to 50 of about 458,745 (334)

Soil and Water Contamination due to Illegal Artisanal Refinery Activities: A Case Study of Okarki Community, Niger Delta Area, Nigeria [PDF]

, 2019
Using a combination of field visits, laboratory experiments and analyses, this study examined the impacts of illegal artisanal crude oil refineries on the environment. Total Hydrocarbons (THC) and heavy metals in the soil and water bodies as well as pr
Galadima, Muhammed, Gwary, Kwatamshuwa, Hasan, Diya'uddeen, Zaria, Usman Abubakar   +3 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Effect of a Care Bundle on the Rate of Blood Culture Contamination in a General Intensive Care Unit

Antibiotics
Background/objectives: Blood culture (BC) contamination is a frequent problem which leads to increased laboratory workload, inappropriate use of antibiotics and the associated adverse events, and increased healthcare costs.
Fani Veini, Michael Samarkos, Pantazis-Michael Voutsinas, Anastasia Kotanidou   +3 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Analysis and Assessment of Hazards Caused by Chemicals Contaminating Selected Items of Firefighter Personal Protective Equipment – a Literature Review

Safety & Fire Technology, 2020
Aim: The aim of the presented paper is to review the literature concerning the risks related to possible contamination with chemical substances of firefighter’s personal protective equipment (i.e.
Sylwia Krzemińska , Małgorzata Szewczyńska   +1 more
doaj   +1 more source

Operational decontamination [PDF]

Biuletyn Wojskowej Akademii Technicznej, 2020
The paper describes the operational decontamination as a system for protection of troops in case of threat of contamination in functional and task-related terms.
Władysław Harmata
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Microbial contamination of food refrigeration equipment

13th World Congress of Food Science & Technology, 2004
Refrigeration systems in chilled rooms in 15 plants processing a variety of foods were studied. These included plants processing raw meat and salads, Chinese ready meals, dairy products, slicing and packing of cooked meats and catering establishments. An initial survey of total numbers of microbes at a total of 891 sites on evaporators, drip trays and ...
Evans, JA, Russell, SL, James, C, Corry, JEL   +3 more
openaire   +2 more sources

Early and efficient detection of Mycobacterium tuberculosis in sputum by microscopic observation of broth cultures. [PDF]

, 2013
Early, efficient and inexpensive methods for the detection of pulmonary tuberculosis are urgently needed for effective patient management as well as to interrupt transmission. These methods to detect M. tuberculosis in a timely and affordable way are not
A Cattamanchi, AD Harries, Benson R. Kidenya, CC Boehme, DA Moore, DA Moore, Daniel W. Fitzgerald, EF Lyamuya, F Ardito, G Shiferaw, GS Ejigu, GV Mukamolova, HP Chien, J Minion, JL Davis, JS Michael, JW Pape, L Caviedes, Lauren E. Webster, Madhukar Pai, N Kiraz, NM Buderer, PD Davies, PE Farmer, PW Ndung’u, Robert N. Peck, Rodrick Kabangila, RP Lazarus, S Keshavjee, Serena P. Koenig, Stephen E. Mshana, W Zhu, Warren D. Johnson, WG Park   +33 more
core   +4 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source