Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar +4 more
wiley +1 more source
Breaking the "idling dilemma" of donated medical equipment: a TDABC-based analysis of health policy failure and a pathway to reform. [PDF]
Zheng H, Fang Y, Pan W.
europepmc +1 more source
Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang +13 more
wiley +1 more source
Study on nutritional status and incidence of sarcopenia in elderly patients with chronic heart failure. [PDF]
Song S, Du H, Lu X, Luo B, Li Z.
europepmc +1 more source
Ultrasoft silicone elastomers often sacrifice surface functionality for mechanical compliance. In Mold Star, low‐molecular‐weight species form a dispersed phase that weakens the network and passivates the surface. Solvent extraction removes this phase, unexpectedly improving both extensibility and metallization performance, enabling conductive ...
Gloria M. D'Amaral +7 more
wiley +1 more source
Development and preliminary evaluation of an AI-enhanced three-dimensional integrated quality model for quality-sensitive indicators in operating room management: a prospective single-center study. [PDF]
Li L, Cai J, Huang X, Cai J.
europepmc +1 more source
ABSTRACT Next‐generation implantable neural‐interfacing devices are increasingly constrained by the coupled demands of electrode miniaturization, electrochemical performance, and implantation infection risk. Femtosecond laser–based hierarchical surface restructuring (HSR) technology has emerged as a scalable, manufacturing‐compatible platform for ...
Henna Khosla +12 more
wiley +1 more source
Malfunctions and Management of Home Medical Equipment in Visiting Nursing Stations and Collaboration with Clinical Engineers. [PDF]
Hamasaka S +3 more
europepmc +1 more source
A multifunctional structural power composite is developed by integrating high‐mass‐loading Zn‐ion hybrid supercapacitors with metal mesh current collectors and aramid nanofiber‐based composite electrolytes, enabling simultaneous load‐bearing capability and enhanced areal energy storage.
Yuseung Choi +8 more
wiley +1 more source
RescueGPT: An Automated System for Detecting Adverse Safety Events in Prehospital Emergency Medical Service Notes With a Zero-Shot Approach With Large Language Models: A Proof-of-Concept Study. [PDF]
Hsieh TYJ +11 more
europepmc +1 more source

