Results 51 to 60 of about 1,376,955 (292)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Modern weapons and military equipments for issue 2-2016 / Современное вооружение и военное оборудование за но. 2-2016 / Savremeno naoružanje i vojna oprema za broj 2-2016

open access: yesVojnotehnički Glasnik, 2016
A military parade in New Delhi / Vojna parada u Nju Delhiju: Dan Republike Indije, 26. januar, i ove godine obeležen je mnogobrojnim manifestacijama i svečanostima čiji sastavni deo je bila i vojna parada u Nju Delhiju.
Nikola M. Ostojić
doaj  

Modern weapons and military equipment for the issue 2-2021

open access: yesVojnotehnički Glasnik, 2021
Tank dreams: Mulling the future of Russian armour design concepts; Elta Systems reveals new passive radar; Rafael demos Drone Dome-L with hard-kill laser capability; Eyes in the sky: How the Orlan-10 UAV is shaping Russian artillery operations;
Dragan M. Vučković
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Modern weapons and military equipments for issue 1-2019 / Современное вооружение и военное оборудование, к выпуску № 1-2019 / Savremeno naoružanje i vojna oprema za broj 1-2019 [PDF]

open access: yesVojnotehnički Glasnik, 2019
Characteristics of modern combat shoes / Характеристики современной боевой обуви / Karakteristike modernih borbenih ...
Miloš M. Jevtić
doaj  

Savremeno naoružanje i vojna oprema za broj 4-2022

open access: yesVojnotehnički Glasnik, 2022
Rusija razvija protivbrodsku balističku raketu; Podmornica klase Kilo sa „pump-jet“ propulzijom.
Dragan M. Vučković
doaj  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Nursing and Midwifery Students Perspective on Clinical Education in Gonabad University of Medical Sciences [PDF]

open access: yesمجله ایرانی آموزش در علوم پزشکی, 2005
Introduction. Continuous evaluation is necessary for improving and promoting the quality of clinical education. The purpose of this study was to determine the views of nursing and midwifery students of Gonabad University of Medical Science about the ...
Fatemeh Hadizadeh   +2 more
doaj  

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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