Results 51 to 60 of about 59,942 (247)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Modern weapons and military equipments for the issue 4-2021
Vojnotehnički Glasnik, 2021 Produženje životnog veka: Velika Britanija pokreće program modernizacije tenka Challenger 2. Ruska armija dobija samohodni protivtenkoski top Sprut-SDM1 SPATG. Francuska je odabrala nuklearni pogon za svoj budući nosač aviona.
Dragan M. Vučković
doaj
Main experimental equipments in water tank.
, 2017 Main experimental equipments in water tank.
Hongyu Shi (3611147) +3 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Formal category theory in $\infty$-equipments I [PDF]
We introduce a generalization of proarrow equipments to the $\infty$-categorical setting, termed $\infty$-equipments. These equipments take the form of particular double $\infty$-categories that support a notion of internal formal higher category theory.
Ruit, Jaco
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Revista Vasca de Administración Pública, 2007 It is analyzed the need of keeping the institution of city council propiertorship of land, as a «separate patrimony» and basically with the purpose of building social housing.
Juan Goñi Ruesgas
doaj +1 more source
Performance Appraisal of Equipments in Opencast Mines [PDF]
, 2013 Mining is a very capital-intensive industry, and it is well known fact that the equipment availability and precise estimation of this utilization are very important since mine managers want to utilize their equipment as effectively as possible to get an ...
Kumar, Pradeep
core